摘要
目的研究社区综合干预在改善2型糖尿病并发冠心病患者血糖、血脂水平及提高患者生命质量中的作用。方法对158例2型糖尿病并发冠心病患者随机分为2组,其中综合干预组87例,对照组71例。在2组原药物及临床干预不变且差异无统计学意义的前提下,对综合干预组进行定点、定时监测,同时进行家庭随访,并与对照组进行前瞻性的对照研究。结果入组前患者空腹血糖(8.45±2.97)mmol/L,总胆固醇(6.38±1.25)mmol/L,甘油三酯(1.86±0.86)mmol/L,高密度脂蛋白胆固醇(1.38±0.81)mmol/L,低密度脂蛋白胆固醇(4.02±1.39)mmol/L。综合干预1年后,患者空腹血糖(7.18±2.06)mmol/L,总胆固醇(5.27±0.98)mmol/L,甘油三酯(1.40±0.1 9)mmol/L,高密度脂蛋白胆固醇(2.01±0.65)mmol/L,低密度脂蛋白胆固醇(1.61±0.95)mmol/L,干预前后比较,差异有统计学意义(P<0.05),与对照组比较,差异有统计学意义(P<0.05)。1年后综合干预组的致残率和病死率分别为0.116%,明显低于对照组的7.14%,5.71%,2组比较差异有统计学意义(P<0.001);综合干预组1年后患者的生命质量、依从性及生活满意度明显提高,且与对照组比较,差异有统计学意义(P<0.01)。结论对2型糖尿病并发冠心病患者进行综合干预有改善血糖、血脂及提高生命质量的作用,可成为治疗2型糖尿病及防治2型糖尿病并发冠心病的医学新模式。
Objective To study the effect of comprehensive community intervention on the improvement of the blood sugar and blood- lipid profile and quality of life in patients of diabetic with coronary heart disease （CHD）. Methods One hundred and fifty- eight cases of diabetic with CPID patients were randomized into two groups：community intervention group （87 cases）and control group（71 cases）. Regular and fixed-time monitoring was carried out and home-visit follow-up and interventional measures were instituted for the intervention group. There were no changes for existing drug use of the two groups. Results Two groups were compared prospectively. The baseline data of the intervention group were： F/3G（8.45 ± 2.97） mmol/L, cholesterol（TC）（ 6.38 ± 1.25 ）mmol/L, triglyceride （TG） （1.86 ± 0.86 ）mmol/L, high density lipoprotein cholesterol（HDL- C） （ 1.38 ± 0.81 ） mmol/L, low density lipoprotein cholesterol（ LDL- C） （4.02 ± 1.39 ） mmol/L. After comprehensive i ntervenion for a year, the TC was （5.27 ± 0.98） mmol/L, TG was （ 1.40 ± 0.19 ） mmol/L, HDL- C was （2.01 ± 0.65 ） mmol/L and LDL-C was （1.61 ± 0.95 ） mmol/L. A significant difference was observed before and after intervention （P 〈 0.05） in the intervention group. There was also a significant difference between the two groups（ P 〈 0.05）. The disablement rate（0） and case-fatality rate（ 1.16 % ）after a year, the rate in the intervention group were much lower than that of control group（7.14 % and 5.71% ）, The difference was significant（P 〈 0. 001 ）. The quality of life, compliance and life satisfaction of patients in the intervention group improved, which were significant compared with the control group（ P 〈 0.01 ） after one year intervention. Conclusion Comprehensive community intervention can improve the blood sugar, blood-lipid and quality of life to the patients who lock into the disease of diabetic patients with coronary heart disease（CHD）, this should become a new medical modality in the prevention and treatment of diabetic patients with coronary heart disease.
出处
《中国公共卫生》
CAS
CSCD
北大核心
2007年第5期577-579,共3页
Chinese Journal of Public Health
关键词
2型糖尿病
冠状动脉疾病
危险因素
干预性研究
type2 diabetes mellitus
coronary disease
risk factors
intervention study
