摘要
目的分析遗传和环境因素与变应性鼻炎发病的关系,为预防和免疫治疗提供依据。方法采用病例对照方法,对174例变应性鼻炎患者进行问卷调查、皮肤试验、血清免疫指标测定,分析变应性鼻炎的相关因素。结果在变应性鼻炎患者中具有家族遗传史的占63.22%。36例变应性鼻炎患者血清总IgE及IL-4水平与32例健康对照组比较显著增高(P<0.001),IL-2水平显著降低(P<0.001),IL-4与IgE水平之间存在显著正相关(r=0.36,P<0.001)。屋尘、螨、吸烟、豚草花粉、多价霉菌、蒿属花粉、蛾、杨树花粉、皮毛类动物、感染、气候突变、刺激性气味等环境因素与变应性鼻炎的关联有统计学意义(P<0.05)。结论家族遗传史、屋尘、螨、吸烟、豚草花粉、多价霉菌、蒿属花粉、蛾、杨树花粉、皮毛类动物、感染、气候突变等环境因素为变应性鼻炎的主要相关因素。
Objective To investigate the relationship of the genetic, environmental factors and allergic rhinitis. Methods Acase - control study was.We assessed 174 allergic rhinitis and 126 healthy subjects. Questionnaire survey, skin test and blood analysis were carried out, and logistic regression analysis was used to probe into the main factors of allergic rhinitis. Results The results showed that allergic rhinitis had obvious genetic factors. The serum total IgE and the level of IL- 4 had significantly increased in 36 allergic rhinitis cases, comparing with control subjects, the level of IL- 2 had significantly decreased. The total serum IgE had significant positive relation with the level of IL - 4 （ r = 0.36, P 〈 0.001） . House dust, dust mites, smoking, ambrosia pollen, moulds, artemistia pollen, moth, poplar pollen, animal hair, infection, weather change, pungent smell et al had significantly relation with allergic rhinitis （P 〈 0.05） . Conclusion Family history of allergy, hose dust, dust mite, smoking, ambrosia pollen, moulds, artemistia pollen, moth, poplar pollen, animal hair, infection, weather change and pungent smell were the main factors of allergic rhinitis.
出处
《中国自然医学杂志》
CAS
2007年第2期112-114,共3页
Chinese Journal of Natural Medicine
