摘要
目的观察托特罗定抑制脊髓损伤所致逼尿肌反射亢进,从而建立低压贮留安全膀胱的临床效果。方法36例脊髓损伤的患者经尿动力检查证实存在明确的逼尿肌反射亢进,逼尿肌漏尿点压力均大于40cmH2O,平均82.4cmH2O,并伴有严重的急迫性尿失禁。全部患者均服用舍尼亭治疗,根据清洁间歇导尿记录判断治疗效果。结果4-8周后32例患者最大导尿容量均大于300ml,与治疗前首次无抑制收缩并发生尿失禁时的平均膀胱容量160ml相比明显增加,其中20例完全无尿失禁发生,获得满意效果,12例患者偶发尿失禁治疗有效,4例患者最大导尿容量小于200ml,治疗无效。总有效率89%。结论托特罗定可以有效的抑制脊髓损伤后发生的逼尿肌反射亢进,可以用来建立低压贮留膀胱。
Objective： Observe the effect of tolterodine to inhibit detrusor hyperreflexia in patients having spinal cord injured, and render to establish a safe neurogenic bladder. Methods： Thirty- six patients with detrusor hyperreflexia had urodyuamic study, their detrusor leak point pressure （DLPP） was all more higher 40cm H2O, the average DLPP was 82.4 cmH2O. All cases had serious urge incontinence. All patients were treated with toherodine and clean intermittent catheterization （CIC）. Result： Thirtytwo patients had improvement 4 - 8 weeks after tolteredine, their maximum residue bladder volume were more than 300ml, comparing with that they would have urge incontinence when the bladder capacity averaged 160ml. Twenty cases had no incontinence, 12 cases had less incontinence, 4 cases had no improvement, and the total effective rate was 89%. Conclusion： Toherodine is effective for neurogenic detrusor hyperreflexia in patients with spinal cord injuy, it could used to establish low pressure bladder.
出处
《华西医学》
CAS
2007年第2期270-271,共2页
West China Medical Journal
关键词
托特罗定
逼尿肌反射亢进
脊髓损伤
tolterodine
detrusor hyperreflexia
spinal cord- injure
