摘要
目的探讨抗惊厥药所致药物超敏综合征(DHS)的临床特征。方法回顾分析20例抗惊厥药所致DHS患者的临床表现、实验室检查、治疗方法、并发症及预后。结果抗惊厥药所致DHS潜伏期长,皮损形态多样,以发疹型为主,常伴有紫癫样斑疹、皮肤肿胀及反复脱屑,多有发热、黏膜损害、浅表淋巴结增大及血常规异常。脏器多受累以肝脏为主、肾脏次之。糖皮质激素治疗有效。结论DHS为具有特征性表现的临床综合征,病程较长,早期、尽量地应用糖皮质激素有助于预后的改善。
Objective： To investigate the anticonvulsantDrug- induced drug hypersensitivity syndrome （DHS）, the clinical features. Methods： Retrospective analysis of 20 cases of patients with ant iconvulsant, complications and prognosis. Results： anticonvulsant drug- induced latency DHS plant lesions varied shapes, with a measles- type, often accompanied by a kind spotted purpura, repeatedly scaling skin swelling and more have a fever and mucosal lesions, superficial Lymph node enlargement and the blood system. Multi - organ involvement mainly in the liver, kidn eytimes. Glucocorticoid therapy. Conclusion： DHS for the performance of charactreristic clinical syndrome, saying longer, in the early days, glucocorticoids foot lot s quarter from 200030 to improve e the prognosis.
出处
《华西医学》
CAS
2007年第2期313-314,共2页
West China Medical Journal
关键词
药物超敏综合征
抗惊厥药
Drug hypersensitivity syndrome
Anticonvulsants
