摘要
目的观察重组人生长激素(rhGH)对特发性矮身材(ISS)患儿的促生长效果。方法选择矮身材患儿98例。按病因分为ISS组30例,生长激素缺乏症(GHD)组68例。二组患儿均予国产rhGH治疗,剂量分别为0.15、0.1 IU/(kg.d),每晚睡前皮下注射,疗程6个月。治疗前及治疗后3、6个月分别测定患儿的身高、体质量、骨龄,计算生长速度。结果治疗3、6个月二组生长速度均显著高于治疗前[ISS组:(7.3±2.9),(7.5±2.7),(3.5±2.1)cm年/,P<0.01;GHD组:(13.2±3.5),(13.5±3.6),(4.0±2.9)cm年/,P<0.01]。治疗6个月后ISS组27例身高增长,GHD组68例身高增长。治疗3、6个月二组同期的生长速度比较,GHD组高于ISS组(P<0.01)。结论国产rhGH治疗ISS患儿安全、总体有效,但疗效存在不均一性,且差于GHD患儿。
Objective To observe the therapeutic effect of Chinese recombinant human growth hormone （rhGH） on the growth of children with idiopathic short stature （ISS）. Methods Ninety - eight children with short stature involved in this study. According to the etiological factors, the children were assigned into 2 groups ： ISS group （ n = 30） and growth hormone deficiency （GHD） group （ n = 68 ）. Both groups were re ceived subcutaneous administration of home - made rhGH for 0. 15 IU/（ kg · d） and 0. 1 IU/（ kg · d） respectively before sleeping within 6 months. The body height, body mass and bone age were measured and the growth rate was calculated before 3 and 6 months after treatment. Results The growth rate of children in two groups 3 and 6 months after treatment were significantly superior to those before treatment [ ISS group ： （7.3 ±2.9） ,（7.5 ±2.7） ,（3.5 ±2.1） cm/year,P 〈 0.01 ;GHD group.. （ 13.2 ± 3.5）, （ 13.5 ± 3.6）, （4.0 ± 2. 9） cm/year,P 〈 0. 01 ]. Six months after treatment, body height increased in 27 of 30 children in ISS groups, and in all the 68 children in GHD group. The growth rate of children in GHD group was concurrently higher than those in ISS group 3 and 6 months after treatment. Conclusions Home - made rhGH is a safe and effective reagent for treatment of ISS, but the inhomogeneity of treatment effect does exist and therapeutic effect in ISS children is inferior to that in GHD children.
出处
《实用儿科临床杂志》
CAS
CSCD
北大核心
2007年第8期591-592,594,共3页
Journal of Applied Clinical Pediatrics
基金
山东省卫生厅基金项目资助(HZ005)
关键词
促生长素类
重组
特发性矮身材
生长激素缺乏症
somatotropins, recombinant
idiopathic short stature
growth hormone deficiency
