摘要
目的研究应用光动力疗法(PDT)治疗皮肤恶性肿瘤的临床疗效及不良反应。方法对10种皮肤恶性肿瘤,共30例患者进行PDT治疗。先后应用中国科学院电子学研究所研制的IEAu-3型金蒸汽激光器(波长627.8nm)和英国DIOMED公司生产的半导体激光器(波长630nm)作为光源,功率密度为100～150mW/cm2,能量密度为150～300J/cm2。光敏剂为血卟啉衍生物(HpD),按5mg/kg给药。在给药后24～72h内针对患者病灶进行PDT治疗。患者共接受1～4个疗程的PDT治疗。治疗前后观察测量患者病灶情况,4周后评价疗效。结果本组30例患者中,完全有效(CR)15例(50%),部分有效(PR)10例(33.3%),无效(NR)5例(16.7%),无疾病进展(PD)病例。总有效(CR+PR)例数共25例(83.3%)。所有病例均未出现严重毒副反应。结论PDT是治疗皮肤恶性肿瘤一种安全、有效的治疗方法,尤其是对临床常见的皮肤基底细胞癌和鳞状细胞癌有较好的疗效。
Objective To study both therapeutic and adverse effects of photodynamic therapy for cutaneous malignant tumors. Methods The IEAu-3 gold vapor laser （wavelength 627. 8nm）, manufactured by the Institute of Electronics, Chinese Academy of Sciences, and diode laser （wavelength 630nm）, manufactured by DIOMED Ltd. （GB）, were employed as the light source. Power density of the both kinds of laser was 100-150mW/cm^2, and energy density was 150-300J/cm^2. Haematoporphyrin derivative （HpD） was used as pohotosensitizer at dosage of 5mg/kg. The patients＇ loci were radiated 12-72h after HpD administration. The patients received 1 to 4 courses of photodynamic therapy. The size of patients＇ focus was measured before and after treatment and the therapeutic effect was appraised 4 weeks later. Results Evaluation of the therapeutic effect in 30 patients showed that 15 patients （50. 0%） responded completely （CR）, 10 patients （33.3%） responded partially （PR）, and 5 patients （16.6%） showed no response （NR）. No patients showed progression of the lesion （PD）. The total response case （CR＋PR） was 25. No adverse effect was found in this group. Conclusions Photodynamic therapy is an effective and safe modality for cutaneous malignant tumor especially for basal cell skin cancer and squamous cell skin cancer.
出处
《解放军医学杂志》
CAS
CSCD
北大核心
2007年第4期396-397,共2页
Medical Journal of Chinese People's Liberation Army
关键词
皮肤肿瘤
光化学疗法
光敏感药
激光
skin neoplasms
photochemotherapy
photosensitizing agents
lasers
