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实验性自身免疫性脑脊髓炎巨噬细胞活性MR成像的研究进展 被引量：5

Progress of macrophage activity on magnetic resonance imaging in experimental autoimmune encephalomyelitis
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摘要 MR成像是监测多发性硬化(MS)病情及其演变、评价疗效的重要手段,实验性自身免疫性脑脊髓炎(EAE)是公认的研究人类多发性硬化的动物模型。常规MR扫描仅能分析MS和EAE炎症反应的继发性改变。巨噬细胞是MS和EAE炎症反应中重要的效应细胞,超微超顺磁性氧化铁(USPIO)粒子能被巨噬细胞摄取,MR成像能显示MS和EAE病灶内吞噬了USPIO的巨噬细胞,分析其炎症反应自身的信息,是动态观察巨噬细胞浸润过程、进一步探索MS免疫病理机制的有效手段。本文综述超微超顺磁性对比剂的特性及其MR成像在EAE和MS病理机制方面的研究进展,评价其发展前景。 MRI is an important tool for monitoring the development of lesions and assessing the efficacy of treatment in multiple sclerosis （MS） in vivo. Experimental autoimmune encephalomyelitis （EAE） is a received animal model for studying MS in human. Conventional MRI can only provide information on the consequences of inflammation. Macrophages play a key role in the inflammatory and tissue degeneration of MS and EAE. Ultra-small supperparamagnetic iron oxide （USPIO） MR imaging can reveal the presence of maerophages in MS and EAE lesions, analyze the information of inflammatory activity itself. It offers a method for monitoring the infiltrations of macrophage and investigating of the etiology and pathogenesis of MS. This article summarizes the USPIO characteristics and USPIO MR imaging in studying the pathogenesis of EAE and MS, demonstrates its clinical benefit.
作者 张海琴 李坤成 于春水
机构地区 首都医科大学宣武医院影像学部放射科
出处 《医学影像学杂志》 2007年第4期402-404,共3页 Journal of Medical Imaging
关键词 超微超顺磁性氧化铁 核磁共振 对比剂 多发性硬化 实验性自身免疫性脑脊髓炎 Ultra-small supperparamagnetic iron oxide Magnetic resonance imaging Contrast agent Multiple sclerosis Experimental autoimmune encephalomyelitis
分类号 R744.5 [医药卫生—神经病学与精神病学] R445.2 [医药卫生—影像医学与核医学]
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参考文献17

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二级参考文献35

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共引文献16

同被引文献71

  • 1董梅,刘瑞春,郭力,李春岩.Wistar大鼠多病程实验性变态反应性脑脊髓炎的模型建立[J].中国免疫学杂志,2006,22(1):78-81. 被引量：12
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引证文献5

二级引证文献8

医学影像学杂志
2007年 第4期

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