摘要
目的:总结灯盏花素在新制剂、新剂型及结构修饰方面的研究进展,为合理开发灯盏花素新剂型提供参考。方法:通过阅读大量近几年灯盏花素在新制剂、新剂型及结构修饰方面的文献,并结合本课题组多年来的研究经验和研究现状,对该领域进行总结概述。结果:灯盏花素结构明确,治疗心脑血管疾病疗效显著,已成为中药研发的热点。结论:虽然灯盏花素新制剂品种众多,但是临床应用并不理想,而对其主要有效成分灯盏乙素进行深入的生物药剂学和药动学研究,进而改善其理化性质,对改善其疗效具有重要意义。
AIM： To summarize the research of breviscapine in the aspects of its new dosage forms and its structural modification, in order to reasonably explore new formulations and derivatives of breviscapine. METHOD： On the basis of combing literatures of breviscapine with the experiences of our group, its development has been summarized and evaluated. RESULT： Breviscapine has clear structure and remarkable effect on cardiovascular diseases, and has been the research hotspot of traditional Chinese medicines. CONCLUSION： The new preparations of Breviscapine are numerous, but clinical application is not ideal. To perform reseaches on scutellarin in biopharmaceutics and pharmacokinetics field is beneficial for improving its physicochemical properties and for enhancing its effects.
出处
《中国天然药物》
SCIE
CAS
CSCD
2007年第3期229-234,共6页
基金
国家自然科学基金资助项目(30430790)
关键词
灯盏花素
灯盏乙素
结构修饰
剂型
Breviscapine
Scutellarin
Preparations
Structural modification
