摘要
P2受体为以ATP、UTP及其类似物激活的受体，分为促离子型P2X受体和促代谢型P2Y受体两大类，其各自又分为许多亚型。许多证据显示，P2Y，特别是P2Y2受体，在痛觉信息调节和痛觉过敏中起着重要作用。ATP和UTP作为P2Y2受体的天然激动剂，是伤害性感受和痛觉过敏信息传递中的重要介质。P2Y2受体参与疼痛的调节可能与辣椒素受体有关。膜片钳分析小鼠背根神经节神经元证明了是P2Y2而非P2Y1受体在ATP诱发的TRPV1介导的热痛过敏反应中起作用。原位杂交组织化学研究结果也显示大鼠腰段脊髓背根神经节中TRPV1mRNA与P2Y2mRNA共同表达。这些证据证明了促代谢型P2Y，受体介导背根神经节神经元中核苷酸对VR1的增敏效应及参与伤害性感受的调节。
There are emerging evidences of roles for P2Y, especially for P2Y2 receptor in hyperalgesia. The nature ligands of P2Y2 receptor are ATP and UTP,which contribute to the transduction of nociception and hyperalgsia signaling. Patch-clamp analyses using mouse DRG neurons indicated that P2Y2 but not P2Y1 receptor involves in ATP induced TRPV-1 mediated thermal hypersensitivity. Moreover, coexpression of TRPV1 mRNA with P2Y2 mRNA was determined in the rat lumbar DRG. Taking all together, these results indicate that P2Y2 contributes to the sensitization effects of nucleotides on VR1 and to modulating nociceptive transmission.
出处
《国际麻醉学与复苏杂志》
CAS
2007年第2期150-153,共4页
International Journal of Anesthesiology and Resuscitation
