摘要
目的探讨氯胺酮复合丙泊酚在小儿静脉麻醉中的应用效果。方法120例手术患儿随机分为氯胺酮组(n=60)和氯胺酮复合丙泊酚组(n=60),观察患儿术前、术中的心率、血压、呼吸频率、血氧饱和度(SpO2)、苏醒时间、苏醒期躁动及恶心、呕吐发生率。结果手术开始即刻,氯胺酮组心率、收缩压、舒张压与术前比较明显升高(P<0.01),氯胺酮复合丙泊酚组仅收缩压比术前升高(P<0.01),2组比较仅舒张压有显著差异(P<0.01);术中各时点氯胺酮组心率、收缩压、舒张压均比术前明显上升(P<0.01),2组比较心率、收缩压、舒张压均有显著差异(P<0.01)。2组术中各时点与术前比较呼吸频率、SpO2均无显著差异(P>0.05)。2组苏醒时间和苏醒期躁动率比较均有显著差异(P<0.01),2组恶心、呕吐发生率无显著差异(P>0.05)。结论氯胺酮复合丙泊酚用于小儿静脉麻醉,术中循环功能稳定,术后苏醒快。
Objective To explore the application effect of ketamine combined with propofol in the intravenous anesthesia on children. Methods One hundred and twenty children were divided into ketamine group and ketamine combined with propofol group. The heart rate （HR）, blood pressure （BP）, respiration rate （RR）, pulse oxygen saturation （SpO2 ）, regaining consciousness time and its restlessness rate and nausea and vomitting rate were observed. Results The moment of surgery started, compared with preoperation,HR,systolic blood pressure （SBP）and diastolic blood pressure （DBP） in the ketamine group rose remarkably （P 〈 0.01 ）, and only SBP rose in the ketamine combined with propofol group （ P 〈 0.01 ）, Only DBP had a remarkable difference between two groups （ P 〈 0.01 ） ; At the different observation time during operation, HR, SBP, DBP were obviously higher than preoperation in ketamine group（P 〈0.01 ） ,HR,SBP,DBP had a remarkable difference between two groups（P 〈0.01 ）. Compared with preoperation, both RR and SpO2 in operation had no significant deviation in two groups. There was obvious difference between two groups in regaining consciousness time and its restlessness rate （P 〈 0.01 ）, but there was no obvious difference in nausea and vomitting rate between two groups （P 〉 0.05）. Conclusion The ketamine combined with propofol in intravenous anesthesia for children keeps circulation stable and regains consciousness rapidly after operation.
出处
《新乡医学院学报》
CAS
2007年第3期267-269,共3页
Journal of Xinxiang Medical University
关键词
氯胺酮
丙泊酚
小儿
麻醉
ketamine
propofol
children
anesthesia
