摘要
目的探讨泌乳素(PRL)与系统性红斑狼疮(SLE)的关系。方法检测91例SLE患者与30例健康成人血清PRL水平。结果SLE患者血清PRL水平明显高于正常对照组,且活动期患者PRL水平显著高于静止期患者,PRL水平与抗ds-DNA水平呈正相关。活动期狼疮性肾炎(LN)患者血清PRL水平显著高于静止期患者,PRL水平与抗ds-DNA水平呈正相关。结论SLE患者血清PRL水平与病情活动相关,可将PRL作为判断SLE病情活动性的指标之一;PRL在SLE发病中可能起一定的作用。
[Objective] To investigate the relationship between prolactin （PRL） and systemic lupus erythematosus （SLE）. [Methods] Serum PRL levels were determined in 91SLE patients and 30 matched healthy controls. [Results] The mean serum PRL levels were significantly higher in SLE patients than those in healthy controls, and the PRL levels were significantly higher in active group than those of inactive group. Serum PRL levels were positively correlated with anti-ds-DNA levels. The PRL levels significantly higher in active lupus nephritis （LN） patients than those of inactive patients. [Conclusions] The results suggest that elevated serum PRL correlates with active disease in SLE which indicates PRL might participate in the pathogenesis of SLE and serum PRL could be a useful marker for disease activity in SLE.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2007年第9期1084-1087,共4页
China Journal of Modern Medicine
关键词
红斑狼疮
系统性
泌乳素
lupus erythematosus
systemic
prolactin
