摘要
目的探讨生存素(survivin,SVV),p185,p53和E-钙黏附素(E-cadherin,E-CD)蛋白在老年大肠癌(CCAP)中的表达及其临床意义。方法应用免疫组化方法检测90例CCAP、20例大肠腺瘤(CA)和20例大肠正常黏膜(CMT)中SVV,p185,p53及E-CD蛋白表达水平,并结合临床病理特征进行分析。结果在CCAP中SVV,p185,p53及E-CD蛋白阳性表达率分别为65.6%(59/90)、52.2%(47/90)、57.8%(52/90)和46.7%(42/90)。CCAP中SVV、p185及P53表达阳性率均显著高于CA和CMT(P<0.05),而E-CD表达阳性率显著低于CA和CMT(P<0.05)。SVV,p185和p53高表达及E-CD低表达与CCAP的Dukes分期、浆膜浸润和淋巴结转移均呈正相关(P<0.05)。p53表达与CCAP组织类型相关(P<0.05)。结论SVV,p185,p53及E-CD表达与CCAP浸润转移密切相关,检测其蛋白表达可作为判断老年大肠癌预后的客观指标。
Objective To investigate the expression of survivin（SW） ,p185, p53 and E-cadherin（E-CD） in colorectal carcinomas in the aged patients（CCAP）. Methods Imrnunohistochemical method was used to detect the expression of SW, p185, p53 and E-CD protein in 90 cases of CCAP,20 of colorectal adenorna（CA） and 20 of colorectal rnucosal tissues（CMT）. The pathological behavior and clinical follow- up survey of CCAP were analyzed. Results The positive rates of SW, p185, p53 and E-CD were 65.6 % （59/ 90） ,52.2% （47/90）,57.8% （52/90） and 46.7% （42/90）, respectively in CCAP. The positive rates of SW, p185 and P53 in CCAP were higher than that in CA and CMT（ P 〈0.05）, but the E-CD was lower than that in CA and CMT（ P 〈0.05）. The high expression of SW, p185, p53 and the low expression of E-CD were positively correlated to the Dukes staging, serosa infiltration and lymph node metastasis of CCAP（P〈0.05）. The expression of p53 was positively correlated to the pathological grading in CCAP（P〈0. 05）. Conclusion The SW, p185, p53 and E-CD expression is closely correlated to the potential of invasion and metastasis in CCAP. SW, p185, p53 and E-CD may be prognostic indicators in colorectal cancer in the aged patients.
出处
《山西医科大学学报》
CAS
2007年第5期410-412,共3页
Journal of Shanxi Medical University
关键词
结直肠肿瘤
腺癌
基因表达调控
免疫组织化学
colorectal carcinoma
adenocarcinoma
gene expression regulation
imrnunohistochemistry
