摘要
目的探讨2型糖尿病合并脂肪肝的主要危险因素。方法采用病例对照研究的方法观察338例2型糖尿病并发脂肪肝和无脂肪肝患者的年龄、身高、体重、腰围、臀围、体重指数(BMI)、腰臀比、空腹血糖(FBG)、C肽、糖化血红蛋白(HbAlc)、谷草转氨酶(AST)、谷丙转氨酶(ALT)、总胆红素(TBIL)、直接胆红素(DBIL)、碱性磷酸酶(ALP)、γ-谷氨酰转肽酶(γ-GT)、肌酐、甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、2 h血糖、2 h C肽等指标:多因素相关分析采用Logistic逐步回归。结果2型糖尿病并发脂肪肝组与无脂肪肝组年龄、身高、FBG、2 h血糖、HbAlc、TBIL、DBIL、ALP、肌酐、TC、LDL无显著性差异(P>0.05),体重、BMI、腰围、臀围、腰臀比、空腹C肽、2hC肽、AST、ALT、γ-GT、TG、HDL有显著性差异(P<0.01);BMI(OR=1.22)、空腹C肽(OR=2.24)与2型糖尿病并发脂肪肝呈正相关,HDL(OR=0.26)与2型糖尿病并发脂肪肝呈负相关。结论肥胖、胰岛素抵抗及脂质代谢紊乱是2型糖尿病并发脂肪肝的主要危险因素。
Objective To explore the risk factors associated with fatty liver in patients with type 2 diabetes mellitus. Methods Compared the serum concentration of fasting blood glucose （FBG） , C-P, HbAlc, AST, ALT, TBIL, DBIL, ALP, γ-GT, Cr, TG, TC,HDL, LDL, 2h BG, 2h C-P and age, stature, weight, body mass index （BMI） , waist circumference, hip ,circumference and wais-thip ratio （WHR） in 338 type 2 diabetic patients with or without fatty liver. The associated variables were analyzed by using logistic regression model. Results There were not differences in the concentration of FBG, 2h BG, HbAlc, TBIL, DBIL, ALP, Ct, TC, LDL and age, stature between with and without fatty liver in T2DM. There were obvious difference in the concentration of C-P, 2h C-P, AST. ALT,γ-GT, TG,HDL and weight, BMI, waist circumference, hip circumference, WHR between with and without fatty liver in T2DM. BMI （OR： 1.22） and C-P （OR： 2.24） were positive correlated to fatty liver in the patients with type 2 diabetes. In contrast, HDL （OR： 0.26） was negative correlated to it. Conclusion Obesity, insulin resistance and dyslipidemia are the chief risk factors of fatty liver in patients with type 2 diabetes mellitus.
出处
《胃肠病学和肝病学杂志》
CAS
2007年第2期171-173,共3页
Chinese Journal of Gastroenterology and Hepatology
关键词
2型糖尿病
脂肪肝
胰岛素抵抗
Type 2 diabetes mellitus
Fatty liver
Insulin resistance
