摘要
目的探讨乳腺癌组织中核转录因子NF-κB和抑癌基因p53的表达及意义。方法用免疫组织化学方法检测NF-κB p65和p53蛋白在58例乳腺癌和20例乳腺增生症组织中的表达。结果乳腺癌中NF-κB表达明显高于乳腺增生症组织,NF-κB表达强度与组织学分级和腋窝淋巴结转移有关,与患者年龄、肿瘤大小、组织学分型无关。乳腺癌中p53蛋白表达明显高于乳腺增生症,p53蛋白的表达与乳腺癌组织学分级有关,与患者年龄、肿瘤大小、组织学分型、淋巴结转移无关。NF-κBp65与p53蛋白在乳腺癌组织中表达呈正相关(r=0.302,P<0.05)。结论提示乳腺癌中NF-κB和p53蛋白的表达与乳腺癌的发生发展有关。
Objective To study the expression and significance of nuclear transcription factor-κB（NF-κB） and tumor suppressor gene p53 protein in breast cancer. Methods Imrnunohistochemical staining was used to detect the expression of NF-κB p65 and p53 protein in 58 cases of breast cancer and 20 cases of proliferative breast disease. Results The expressive degree of NF-κB in breast cancer was significantly higher than in proliferative breast disease. The positive intensities of NF-κB was associated with histologie grading and axillary lymph node metastasis, but was not associated with age, tumor size, and histological type. The expressive degree of p53 is significantly higher than in proliferative breast disease. The positive intensities of p53 were associated with histologic grading, but were not associated with age, tumor size, histological type and axillary lymph node metastasis. The expression of NF-κB and p53 protein were significantly positive correlated in breast carcinoma （r = 0. 302, P〈0. 05）. Conelusion It is suggested that the abnormal expression of NF-κB and p53 are associated with the pathogenesis and development of breast cancer.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
2007年第5期342-344,F0003,共4页
Cancer Research on Prevention and Treatment
关键词
乳腺癌
NF-ΚB
P53蛋白
免疫组织化学
Breast carcinoma
NF-κB
Tumor suppressor gene p53
Immunohistochemistry
