期刊文献+

青年食管鳞癌和贲门腺癌组织中Ras相关区域家族1A蛋白的表达 被引量:1

Expression of RASSF1A protein in esophageal squamous cell carcinoma and gastric cardia adenocarcinoma tissue from young patients at high incidence area in Henan
下载PDF
导出
摘要 目的探讨青年食管鳞癌(SCC)和贲门腺癌(GCA)组织中Ras相关区域家族1A(RASSF1A)蛋白的表达变化特征。方法采用免疫组织化学检测河南省林州地区青年SCC和GCA组织RASSF1A蛋白表达,将癌组织阳性结果分为弥漫型、灶性、镶嵌型,并分析其与临床病理变化的关系。结果SCC和GCA组织中RASSF1A阳性表达频率均较高(83%(10/12)vs89%(8/9)),与对应正常组织中的表达差异无统计学意义(P>0.05),但表达类型并不相同。食管鳞癌以镶嵌型(4例)和灶性(4例)较多,弥漫型(2例)次之;食管正常组织以乳头性(3例)和灶性(3例)较多,镶嵌型(2例)次之,无弥漫型表达;贲门腺癌组织以灶性为主(6例),镶嵌型(2例)次之,无弥漫型表达;贲门正常组织以弥漫型(5例)较多,另有灶性(4例)表达。RASSF1A蛋白表达与SCC和GCA的转移、分化和浸润程度无相关性。结论RASSF1A蛋白阳性表达是河南高发区青年食管鳞癌和贲门腺癌组织中常见的分子事件,可能在食管和贲门癌变过程中起一定作用。 Aim :To detect the expression of RASSF1A protein in young patients with esophageal squamous cell carcinoma (SCC) and gastric cardia adenocarcinoma (GCA). Methods:Immunohistochemistry (ABC) method was applied to detect the expression of RASSF1A protein in SCC, GCA and the corresponding normal tissue in young patients from Linzhou, Henan. Results: The positive immunostaining rate for RASSF1A in SCC and GCA tissue was 83% (10/12), 89% (8/9), respectively, which was similar to that in corresponding normal tissue (P 〉 0.05). However, the immunostaining patterns were different. In SCC, there were "scattered" (4 cases) , "focal" (4 cases) and "diffused" (2 cases) immunosraining patterns; in normal esophageal tissue the "papillary" (3 cases) and "focal" (3 cases) immunostaining patterns were Common ; in GCA the "focal" (6 cases) pattern was predominant, and "scattered" (2 cases) pattern was present ; there were "diffused" (5 cases) and "focal" (4 cases) patterns in the normal gastric cardia tissue. No significant relationship was observed among the rate of RASSF1A protein positive expression and differentiation, metastasis, or invasion depth both in SCC and GCA. Conclusion: The results demonstrate that RASSF1A protein expression is a frequent molecular event in SCC and GCA, suggesting that RASSF1A may play an important role in esophageal and gastric cardia carcinogenesis.
出处 《郑州大学学报(医学版)》 CAS 北大核心 2007年第3期409-411,共3页 Journal of Zhengzhou University(Medical Sciences)
基金 河南省医学创新人才工程基金资助项目200084 国家自然科学基金资助30025016 国家科技部"863"重大基金资助项目2007
关键词 Ras相关区域家族1A蛋白 青年 食管鳞癌 贲门腺癌 高发区 RASSF1A protein youth esophageal squamous cell carcinoma gastric cardia adenocarcinoma high incidence area
  • 相关文献

参考文献7

  • 1王立东,高文俊,杨万才,李晓芳,李健,邹建湘,王道存,郭瑞霞.林州市人民医院9a间食管、贲门癌3933例分析[J].河南医科大学学报,1997,32(1):9-11. 被引量:43
  • 2刘忠,何欣,郭涛,吴会芳,王俊宽,范宗民,王立东.辉县市人民医院17年(1987~2003)食管和贲门癌3660例住院病例分析[J].河南医学研究,2005,14(1):42-44. 被引量:2
  • 3Wong ML,Tao Q,Fu L,et al.Aberrant promoter hypermethylation and silencing of the critical 3p21 tumor suppressorgene,RASSF1A,in Chinese esophageal squamous cell carcinoma[J].Int J Oncol,2006,28(3):767
  • 4Agathanggelou A,Cooper WN,Latif F.Role of the Rasassociation domain family 1 tumor suppressor gene in human cancers[J].Cancer Res,2005,65(9):3497
  • 5Wang LD,Hong JY,Qiu SL,et al.Accumulation of p53 protein in human esophageal precancerous lesions:a possible early biomarker for carcinogenesis[J].Cancer Res,1993,53(8):1 783
  • 6Yates DR,Rehman I,Meuth M,et al.Methylational urinalysis:a prospective study of bladder cancer patients and age stratified benign controls[J].Oncogene,2006,25(13):1 984
  • 7李学民,范宗民,吕晓东,冯笑山,范雷,王俊宽,暴志芹,何欣,高珊珊,王立东.河北省磁县医院1973—2005年4418例食管癌和贲门癌病例分析[J].肿瘤基础与临床,2006,19(6):445-447. 被引量:7

二级参考文献8

共引文献49

同被引文献18

  • 1李兆申,徐晓蓉,许国铭,邹多武,孙振兴,王雯,叶萍,陆建萍.反流性食管炎的临床特征分析[J].中华消化内镜杂志,2005,22(5):315-318. 被引量:95
  • 2王立东,李吉林,张彦霞,焦新英,王俊宽,杜娴娟,吴会芳,范宗民,何欣,宋昕,申秋,樊慧,高姗姗,常扶保,常智慧,吴爱群,邢国兰.河南贲门癌高发区贲门癌发生部位分析[J].郑州大学学报(医学版),2007,42(3):389-393. 被引量:14
  • 3ZOchbauer-Miiller S, Lain S, Toyooka S, Virmani AK, Toyooka KO, Seidl S, Minna JD, Gazdar AF. Aberrant methylation of multiple genes in the upper aerodigestive tract epithelium of heavy smokers. Int J Cancer 2003; 107:612-616.
  • 4Herman JG, Graft JR, Myohanen S, Nelkin BD, Baylin SB. Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. Proc Natl Acad Sci U S A 1996; 93:9821-9826.
  • 5Fan YJ, Song X, Li JL, Li XM, Liu B, Wang R, Fan ZM, Wang LD. Esophageal and gastric cardia cancers on 4238 Chinese patients residing in municipal and rural regions: a histopathological comparison during 24-year period. World ] Surg 2008; 32: 1980-1988.
  • 6Donninger H, Vos MD, Clark GJ. The RASSFIA tumor suppressor. J Cell Sci 2007; 120:3163-3172.
  • 7Yazici H, Terry MB, Cho YH, Senie RT, Liao Y, Andrulis I, Santella RM. Aberrant methylation of RASSFIA in plasma DNA before breast cancer di- agnosis in the Breast Cancer Family Registry. Cancer Epidemiol Biornarkers Prev 2009; 18:2723-2725.
  • 8Yanagawa N, Tamura G, Oizumi H, Kanauchi N, Endoh M, Sadahiro M, Motoyama T. Promoter hypermethylation of RASSFIA and RUNX3 genes as an independent prognostic prediction marker in surgically resected non-small cell lung cancers. Lung Cancer 2007; 58:131-138.
  • 9Oliveira C, Velho S, Domingo E, Preto A, Hofstra RM, Hamelin R, Yamamoto H, Seruca R, Schwartz S Jr. Concomitant RASSFIA hypermethylation and KRAS/BRAF mutations occur preferentially in MSI sporadic colorectal cancer. Oncogene 2005; 24: 7630-7634.
  • 10Lo PH, Xie D, Chan KC, Xu FP, Kuzmin I, Lerman MI, Law S, Chua D, Sham J, Lung ML. Reduced expression of RASSFIA in esophageal and nasopharyngeal carcinomas significantly correlates with tumor stage. Cancer Lett 2007; 257:199-205.

引证文献1

二级引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部