摘要
目的检查补肾壮阳类中药及中药保健品中非法掺入化学药西地那非。方法以高效液相色谱-质谱联用(HPLC-MS)对补肾壮阳提取液进行液相色谱-质谱分析。通过与西地那非对照品的色谱及质谱相比较进行定性鉴别。结果在20批补肾壮阳中药制剂中,有2批检出西地那非。结论针对这种违法违规行为必须采取措施严厉打击。
OBJECTIVE To identify sildenafil citrate illegally mixed in traditional Chinese medicine（TCM） preparations. METHODS HPLC-MS method was used for the .separation and determination of the organic extract of TCM preparations. The compounds illegally added into the TCM preparations were identified according to the chromatographic behavior and mass spectral data by comparison with those of control. RESULTS 20 batches TCM preparations were determined,batches of which contained sildenafil citrate. CONCLUSION Measures must be taken strictly to prevent this illegal behavior.
出处
《齐鲁药事》
2007年第5期277-278,共2页
qilu pharmaceutical affairs
