摘要
目的:观察胸段硬膜外阻滞法联合中药对哮喘大鼠血清中白细胞介素4(IL-4)、干扰素-γ(IFN -γ)浓度的影响,探讨该方法防治哮喘的作用机制,为临床治疗哮喘提供理论和实验依据。方法:将40只健康大鼠(雌雄各半)随机分为5组:即空白组(A组),哮喘组(B组),中药组(C组),硬膜外阻滞组(D组),硬膜外阻滞联合中药组(E组)。B、C、D和E组进行哮喘造模。D和E组同时用制成硬膜外阻滞模型。C和E组给予中药灌胃。15d后,分别检测各组大鼠血清中IL-4、IFN-γ的浓度。结论:胸段硬膜外阻滞法联合中药可以降低哮喘大鼠血清中IL-4、升高哮喘大鼠血清中IFN-γ的浓度,该方法通过影响细胞因子的分泌,从而达到防治哮喘的目的。
Objective: To observe the effect of thoracic part extradural block combined with a Chinese herbal medicine to the density of IL - 4 and IFN -γfrom the asthma big rat serum, inquiry into the mechanism of that method prevention and cure asthma, for clinical treatment the asthma provide theories and experimental basis. Methods:40 healthy big rats were divided into S sets randomly (bisexual each half), give respectively dissimilarity processing, 15 divas, examine each density of big rats' IL - 4 and IFN -γ. Conclusion: the thoracic part extradural block and treatment by Chinese herbs can make the IL - 4 in the asthma big rat serum lower, the IFN-γheats up.
出处
《中医药信息》
2007年第3期58-59,共2页
Information on Traditional Chinese Medicine
基金
黑龙江省自然科学基金资助项目(D2004-31)
