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青蒿素及其衍生物的抗白血病作用 被引量：2

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摘要 研究表明青蒿的提取物青蒿素具有抗白血病作用。由于青蒿素难溶于水和油，于是半合成了几种水溶性的衍生物，如蒿甲醚、蒿乙醚和青蒿琥酯等。二氢青蒿素是青蒿素衍生物的主要活性代谢产物。青蒿素及其衍生物主要通过抑制细胞增殖、诱导细胞凋亡和抑制血管生成而发挥抗白血病作用。它对白血病细胞有较强的靶向性，并可克服多药耐药，与传统化疗药无交叉耐药。因青蒿素安全而低毒，故有望成为一种新的抗白血病药。
作者 龚峻梅（综述） 杜庆锋（审校） 刘晓力（审校）
机构地区 南方医科大学南方医院血液科
出处 《国际输血及血液学杂志》 CAS 2007年第3期264-266,共3页 International Journal of Blood Transfusion and Hematology
关键词 青蒿素 白血病 抗白血病药
分类号 R978.61 [医药卫生—药品]
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参考文献24

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共引文献132

同被引文献25

  • 1周琳,张小松.HPLC测定蒿甲醚胶丸的含量[J].华西药学杂志,2005,20(4):341-343. 被引量：9
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  • 3孙卫华.抗疟疾复方制剂--COARTEM~[J].中国药师,2006,9(10):965-966. 被引量：4
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二级引证文献9

国际输血及血液学杂志
2007年 第3期

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