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鼻渊舒口服液对急性鼻窦炎大鼠基因表达谱影响的实验研究 被引量：4

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摘要 目的应用基因芯片技术研究鼻渊舒口服液对实验性急性鼻窦炎(ARS)大鼠基因表达谱的影响。方法SD大鼠随机分为模型组、治疗组和正常组,模型组和治疗组依据Y.Gel的改良方法造模,正常组不做任何处理。造模成功后治疗组给予鼻渊舒口服液灌胃,处死动物,取鼻粘膜组织,选用Ol-igo-60S芯片,对鼻渊舒治疗ARS大鼠的差异表达基因谱进行初步研究和分析。结果实验发现24条与鼻渊舒治疗作用直接相关的基因。其中PKC、Rgc32 protein、Acox2基因与鼻渊舒治疗ARS密切相关。结论表明鼻渊舒口服液可以影响许多基因的表达,并从多途径、多环节、整体上调控炎症反应。
作者 朱天民 熊大经 袁晓辉 许必芳 曾秀燕 李辉
机构地区 成都中医药大学 四川省成都市儿童医院 广东省广州市干部疗养院
出处 《浙江中医杂志》 2007年第5期297-299,共3页 Zhejiang Journal of Traditional Chinese Medicine
关键词 急性鼻窦炎 鼻渊舒口服液 大鼠 基因芯片 差异表达基因
分类号 R285.5 [医药卫生—中药学]
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参考文献13

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共引文献12

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浙江中医杂志
2007年 第5期

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