摘要
目的观察苦参素联合拉米夫定对慢性乙型肝炎（C型）肝纤维化指标的影响。方法慢性乙型肝炎患者60例分为治疗组和对照组各30例,两组基础治疗相同。治疗组前2个月用苦参素葡萄糖注射液静脉滴注,以后改用苦参素胶囊口服,同时服用拉米夫定。对照组用大黄蜇虫丸口服。结果治疗结束时,治疗组ALT复常率100%,HBeAg阴转率61%,HBV-DNA阴转率95%,均明显高于对照组（分别为89%、10%和8%）（P＜0．01）;血清肝纤维化指标透明质酸（HA）、层粘蛋白（LN）、前胶原Ⅲ肽（PCⅢ）、Ⅳ型胶原（Ⅳ-C）与对照组比较差异有统计学意义（P＜0．01）。结论苦参素联合拉米夫定治疗慢性乙型肝炎可促进肝功能恢复正常、HBV-DNA阴转和肝纤维化指标迅速降低。
Objective To explore the effect on the physiological indexes of liver fibrosis by combined use of lamivudine and coussein in treating C chronic hepatitis B. Methods Sixty chronic hepatitis B patients were randomly divided into 2 groups：30 in the treatment group and 30 in the control group. The 2 groups received the same basic treatmem. The treament group was given intravenous drip of coussein during the first two months, followed by oral tak-ing of coussein capsule. The control group was given compound shell liver softening tablets orally. Results After one year of treatment,ALT turned normal 100 % , HBeAg became negative 61% , HBV-DNA became negative 95 % in the treatment group, all were significantly higher than those in the control group（89 % , 10 % and 9 % respectively） （P 〈 0.01 ）. The indexes of serum fibrosis（HA, LN, PC lit and Ⅳ-C） in the treatment group were markedly different from those in the control group（P 〈 0.01）. Conclusion Combined use of coussein and lamivudine is effective in treating chronic hepatitis B and preventing liver fibrosis. As the liver functions become normal, and HBeAg and HBV-DNA turn negative, the indexes of fibrosis quickly drop.
出处
《中国基层医药》
CAS
2007年第4期596-597,共2页
Chinese Journal of Primary Medicine and Pharmacy
