摘要
目的:研究解毒祛瘀滋阴药对系统性红斑狼疮(SLE)患者外周血淋巴细胞Bax/Bcl-2基因mRNA的影响。方法:临床选择SLE患者45例,随机分单用激素组和并用中药组,利用RT-PCR法检测各组治疗前后Bax/Bcl-2基因mRNA表达情况。结果:SLE患者的Bax/Bcl-2基因表达比值明显低于正常人(P<0.001);活动期低于缓解期(P<0.05);治疗后两组Bax/Bcl-2基因表达比值明显上升,而并用中药组治疗后明显高于单用激素组(P<0.05)。结论:激素合解毒祛瘀滋阴药治疗,能明显提高SLE患者外周血淋巴细胞Bax/Bcl-2基因mRNA表达比值,这可能与其诱导淋巴细胞凋亡、调节免疫内环境的作用有关。
Objective ：To investigate the adjustable effect of Jiedu Quyu Ziyin Recipe （JQZR） on the expression of Bax/ Bcl-2 in lymphocytes of peripheral blood in systemic lupus erythematosus （SLE）. Methods ：45 patients with SLE were chosen and divided into 2 groups randomly, the western medicine group and the integrated Chinese and Western medicine group. The expressions of Bax/Bcl-2 in lymphocytes were checked by RT-PCR methods. Results： The expressions of Bax/ Bcl-2 in SLE patients were obviously lower than that in the normal group（ P 〈 0. 001 ） ; The expressions of Bax/Bcl-2 in active stage were obviously lower than that in remission stage group（ both P 〈 0.05 ）. The ratio of Bax/Bcl-2 rose in the both groups after treatment, While the ratio in the integrated Chinese and Western medicine group was higher obviously than in the western medicine group（ P 〈 0.05 ）. Conclusion ： Treating SLE with integrated JQZR and prednisone can more effectively promote the ratio of Bax/Bcl-2 in lymphocyte of peripheral blood, and which is related to induce the apoptosis of lymphocyte and aojust its inter immune environment.
出处
《浙江中西医结合杂志》
2007年第6期333-335,共3页
Zhejiang Journal of Integrated Traditional Chinese and Western Medicine
