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基质金属蛋白酶及其抑制剂与喉癌的浸润和转移 被引量：1

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摘要 喉癌是头颈部常见的恶性肿瘤，喉癌的浸润与转移是影响治疗效果和预后的主要因素。基质金属蛋白酶及基质金属蛋白酶抑制剂是调节许多生理和病理过程中细胞外基质及基底膜有序降解和重塑的重要分子。细胞外基质和基底膜的降解在喉癌和其他肿瘤的浸润转移过程中起重要作用，基质金属蛋白酶及其抑制剂在细胞外基质和基底膜的代谢平衡中起关键作用，因而与喉癌的浸润转移密切相关。本文对基质金属蛋白酶及其抑制剂在喉癌中的表达与喉癌浸润转移及预后的相关性作一综述，并对指导喉癌治疗进行了展望。
作者 孟粹达 徐艳萍
机构地区 吉林大学第二医院耳鼻咽喉头颈外科
出处 《国际耳鼻咽喉头颈外科杂志》 2007年第3期174-177,共4页 International Journal of Otolaryngology-Head and Neck Surgery
关键词 基质金属蛋白酶(Matrix Metalloproteinases) 喉肿瘤(Laryngeal Neoplasms) 肿瘤转移(Neoplasm Metastasis)
分类号 R73 [医药卫生—肿瘤]
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参考文献19

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同被引文献11

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国际耳鼻咽喉头颈外科杂志
2007年 第3期

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