摘要
目的评价3组方案治疗肝硬化上消化道出血的疗效、不良反应及成本-效果。方法对167例肝硬化上消化道出血患者在常规治疗基础上,随机分为3组,分别使用不同的治疗方案(Ⅰ组:小剂量垂体后叶素+硝酸甘油+法莫替丁;Ⅱ组:奥曲肽+法莫替丁;Ⅲ组:奥曲肽+奥美拉唑)。观察其疗效及不良反应,并运用药物经济学成本-效果分析方法进行回顾性分析。结果3组总有效率分别为90.7%,93.0%和98.2%,其差异无显著性意义(P>0.05)。Ⅰ组中13例有轻度副作用,Ⅱ组、Ⅲ组无副作用。3组成本-效果比分别为26.84,60.14和61.47,Ⅰ组明显优于Ⅱ组、Ⅲ组(P<0.05)。结论3组方案均为肝硬化上消化道出血安全、有效的治疗方法,可根据患者具体情况灵活选用。
Objective To evaluate the therapeutic effects,adverse reactions and the cost effectiveness between three groups projects of curing hepatocirrhosis portal hypertension leading to upper gastrointestinal hemorrhage. Methods Divided 167 patients of hepatocirrhosis portal hypertension leading to upper gastrointestinal hemorrhage into three groups at random on the base of routine treatment, used different RX respectively （ Group Ⅰ ： little dosage Pituitrinum ＋ Nitroglycerin ＋ Famotidine ; Group Ⅱ ： Octreotide ＋ Famotidine ; Group Ⅲ： Octreotide ＋ Omeprazole ）. Observed their therapeutic effects and adverse reactions, used the cost - effectiveness analysis of medication economy to carry out retrospective analysis. Results After treatment, the total effective rate of three groups were 90. 7%, 93.0% and 98.2% respectively. Their differences were not very clearly （ P 〉 0. 05 ）. 13 cases of Group Ⅰ had a slight side - effect, both Group Ⅱ and Group Ⅲ had no side - effect. The cost - effectiveness rations of three groups were 26. 84, 60. 14 and 61.47, Group Ⅰ is apparently superior to Group Ⅱ and Group Ⅲ（ P 〈 0. 05 ）. Conclusion All of three groups RX are secure and effective RX of hepatocirrhosis portal hypertension leading to upper gastrointestinal hemorrhage, they can be chosen according to concrete conditions of patients.
出处
《医药论坛杂志》
2007年第8期44-45,共2页
Journal of Medical Forum
关键词
治疗方案
肝硬化
上消化道出血
成本-效果分析
RX
Hepatocirrhosis
Upper gastrointestinal hemorrhage
Cost - effectiveness analysis
