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疾病状态下高密度脂蛋白的功能缺陷 被引量：7

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摘要 在炎症、脂质紊乱以及代谢性疾病中,高密度脂蛋白(HDL)抗动脉粥样硬化特性会受到影响。这种功能的损伤反映在HDL的组成、代谢及相关的生物学活性上。HDL的功能缺陷会影响血管内HDL代谢,使胆固醇逆转运、抗炎及抗氧化能力下降。HDL功能缺陷和浓度降低的共同作用,加速了动脉粥样硬化的发生。对HDL功能异常的检测有助于进一步了解动脉粥样硬化发生的机制,针对HDL功能和数量的治疗有希望在未来成为抗动脉粥样硬化治疗的新靶点。
作者 严晓伟 包婺平
机构地区 中国医学科学院 中国协和医科大学 北京协和医院 心内科
出处 《中国循环杂志》 CSCD 北大核心 2007年第2期152-154,共3页 Chinese Circulation Journal
关键词 动脉粥样硬化 高密度脂蛋白 抗炎作用 抗氧化作用 胆固醇逆转运
分类号 R541.4 [医药卫生—心血管疾病]
  • 相关文献

参考文献18

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二级参考文献29

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共引文献4

同被引文献71

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引证文献7

二级引证文献33

中国循环杂志
2007年 第2期

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