摘要
目的:探讨寻常型银屑病患者炎琥宁注射液治疗前后外周血CD3+,CD4+,CD8+T细胞变化情况。方法:40例患者中予炎琥宁注射液240 mg加入0.9%生理盐水250 mL^500 mL中静滴,1次/d;内服中药银花虎杖饮(加减),1剂/d,分2次服;苦豆子油外用,2次/d,治疗4周。治疗前及治疗后检测患者外周血CD3+,CD4+,CD8+T细胞。选择门诊健康体检者40例作为对照组。结果:治疗组有效率为85%,CD3+,CD4+,CD8+T细胞以及CD3+/CD4+比值与治疗前比较差异有统计学意义(P<0.01)。结论:炎琥宁注射液对寻常型银屑病疗效肯定,其在改善症状的同时亦能纠正患者外周血T细胞及其亚群的失衡状态。
Objective： To explore the alternative conditions of peripheral blood T-cell CD3^＋ , CD4^＋ and CD8^＋ of the patients with psoriasis vulgaris treated by Yanhuning injection. Methods： All 40 patients with psoriasis vulgaris were injected Yanhuning injection 240 mg added 0.9% NaCl 250 mL-500 mL for intravenous drip for one time a day and were given oral administration of traditional Chinese drugs Yinhua-huzhang （decoction） for one dosage a day （twice a day）, the oil of sophora was used as external application for twice a day and the treatment continued for four weeks. Peripheral blood T-cell CD3^＋ , CD4^＋ and CD8^＋ of the patients were detected at the beginning and the end of the treatment. Results： Forty healthy persons were selected as control group and the effectual rate of the treatment group was 85 %. Comparing with the ratio between T-cell CD3^＋, CD4^＋, CD8^＋ and CD3^＋ / CD4^＋ before treatment, the difference between them has statistically significance （P 〈 0.01 ）. Conclusions： The therapeutic effects of Yanhuning injection in treatment of psoriasis vulgaris are affirmative. It can not only improve clinic symptoms but also correct the abnormalities of the patients＇ peripheral blood T-cell and T-cell subgroup.
出处
《山西职工医学院学报》
CAS
2007年第2期14-15,共2页
Journal of Shanxi Medical College for Continuing Education
