期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

基于甲病毒的RNA复制子疫苗 被引量：1

下载PDF
导出
摘要 RNA复制子疫苗利用源自病毒能够自主复制的RNA,结构蛋白基因由外源抗原基因取代,保留了非结构蛋白基因,非结构蛋白可控制载体RNA在胞浆中高水平复制和外源基因的高水平表达。RNA复制子疫苗克服了传统疫苗和普通DNA疫苗存在的缺点,具有免疫效果显著、安全性好、应用范围广等优点,具有很好的应用前景。用于RNA复制子疫苗的载体主要源自甲病毒,本文以甲病毒载体为例,简要阐明RNA复制子疫苗的基本原理和特点,并对其应用作一综述。
作者 王红仁 李明远
机构地区 四川大学华西基础医学与法医学院微生物学教研室
出处 《微生物学免疫学进展》 2007年第2期72-75,共4页 Progress In Microbiology and Immunology
关键词 RNA复制子 甲病毒 疫苗 凋亡
分类号 R392 [医药卫生—免疫学]
  • 相关文献

参考文献27

  • 1Rayner JO,Dryga SA,Kamrud KI.Alphavirus vectors and vaccination[J].Rev Med Virol 2002,12:279-296.
  • 2杨丽琛,杨晓光.DNA免疫研究进展[J].卫生研究,2006,35(1):110-114. 被引量：4
  • 3Rheme C,Ehrengruber MU,Grandgirard D.Alphaviral cytotoxicity and its implication in vector development[J].Exp Physiol 2004,90(1):4-52.
  • 4仇华吉,李卫平,童光志.RNA复制子疫苗[J].中国生物工程杂志,2003,23(3):44-49. 被引量：5
  • 5Leitner WW,Hwang LN,Deveer MJ,et al.Alphavirus-based DNA vaccine breaks immunological tolerance by activating innate antiviral pathways[J].Nat Med 2003,9(1):33-39.
  • 6Zhou A,Hassel BA,Silverman RH.Expression cloning of 2-5A-dependent RNase:a uniquely regulated mediator of interferon action[J].Cell 1993,72:753-765.
  • 7Player MR,Torrence PF.The 2-5A system:modulation of viral and cellular processes through acceleration of RNA degradation[J].Pharmacol Ther 1998,78:55-113.
  • 8Williams BR.PKR:a sentinel kinase for cellular stress[J].Oncogene 1999,18:6112-6120.
  • 9Stojdl DF,Abraham N,Knowles S,et al.The murine double-stranded RNA-dependent protein kinase PKR is required for resistance to vesicular stomatitis virus[J].Virol 2000,74(20):9580-9585.
  • 10Gil J,Alcami J,Esteban M.Induction of apoptosis by double-stranded-RNA-dependent protein kinase (PKR) involves the alpha subunit of eukaryotic translation initiation factor 2 and NF-kappa B[J].Mol Cell Biol 1999,19 (7):4653-4663.

二级参考文献59

  • 1Hyam I L.Accessories for naked DNA vaccines.Nature Biotechnology,1997,15:619-620.
  • 2Stenger S,Modilin RL.Cytotoxic T cell responses to intracellular pathogens.Curr Opin Immunol,1998,10 (4):471-477.
  • 3Mccluskie M J,Davis HL.Novel strategies using DNA for the induction of mucosal immunity.Crit Rev Immunnol,1999,19 (4):303-329.
  • 4Roman M,Elena MO,Goodman JS,et al.Immunostimulatory DNA sequence function as T helper-1-promoting adjuvants.Nature Med,1997,3(8):849-854.
  • 5Zimmernamm S,Gtrer O,Hausmann S,et al.CpG oligodeoxynuletides triggeer protective and curative Th1 responses in lethal murine leishmanisais.The journal of Immunology,1998,160:3627-3630.
  • 6Chu RS,Targoni OS,Krieg AM,et al.CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Th1) immunity.J Exp Med,1997,186:1623-1631.
  • 7Krieg AM,Yi Ak,Matson S,et al.CpG,motifs in bacterial DNA triggr direct B-cell activation.Nature,1995,374 (6522):546-549.
  • 8Michael A B,Stephen A J.Biological features of genetic immunization.Vaccine,1997,15 (8),788-791.
  • 9Xiang Z Q,Spitalnik S L,Cheng J,et al.Immune response to nucleic acid vaccines to rabies virus.Viriology,1995,209:569-579.
  • 10Singh M,Briones M,Inaba K,et al.Proc Natl Acad Sci USA,2000,97 (2):811-816.

共引文献7

同被引文献12

  • 1余云舟,孙志伟,刘志刚,俞炜源.基于DNA的Semliki森林病毒复制子载体体内外高水平表达外源基因[J].生物化学与生物物理进展,2006,33(1):87-94. 被引量：9
  • 2Kenneth Lundstrom. Alphaviruses in Gene Therapy [J]. Viruses, 2009, 1(1): 13-25.
  • 3Moran TP, Burgents JE, Long B, et al. Alphaviral vector-transduced dendritic cells are successful therapeutic vaccines against neu-over expressing tumors in wild-type mice [J]. Vaccine, 2007, 25(36): 6604-12.
  • 4Vaha-Koskela MJ, Kuusinen TI, Holmlund-Hampf JC, et al. Semliki Forest virus vectors expressing transforming growth factor beta inhibit experimental autoimmune encephalomyelitis in Balb/c mice[Jl. Biochem Biophys Res Commun, 2007, 355(3): 776-81.
  • 5Riezebos-Brilman A, Regts J, Chen M, et al. Augmentation of alphavirus vector-induced human papilloma virus-specific immune and anti-tumour responses by coexpression of interleukin-12 [J]. Vaccine, 2009, 27(5): 701-7.
  • 6Maatta AM, Makinen K, Ketola A, et al. Replication competent Semliki Forest virus prolongs survival in experimental lung cancer [J]. Int J Cancer, 2008, 123(7): 1704-11.
  • 7Quinn K. Effect of intranasal administration of Semliki Forest virus recombinant particles expressing interferon-β on the progression of experimental autoimmune encephalomyelitis [J]. Mol Med Rep, 2008, 1(3): 335-42.
  • 8Capozzo A, Ramirez K, Polo J, et al. Neonatal immunization with a Sindbis virus-DNA measles vaccine induces adult-like neutralizing antibodies and cell-mediated immunity in the presence of maternal antibodies[J]. J Immunol, 2006. 176(9): 5671-81.
  • 9Lundstrom K. Biology and application of alphavimses in gene therapy [J]. Gene Ther, 2005, 12(Suppl 1): S92-7.
  • 10Durso RJ, Andjelic S, Gardner JP, et al. Novel alphavirus vaccine encoding prostate-specific membrane antigen elicits potent cellular and humoral immune responses [J]. Clin Cancer Res, 2007, 13(13): 3999-4008.

引证文献1

二级引证文献5

微生物学免疫学进展
2007年 第2期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部