摘要
目的:评价健择+顺铂(简称GP)化疗联合适形放疗对局部晚期胰腺癌的疗效。方法:54例局部晚期胰腺癌患者中25例采用GP化疗结合适形放疗(治疗组),29例单纯应用GP化疗(对照组),对比两者的疗效。结果:(1)治疗组有效率为68.0%,对照组有效率为37.9%,两组差异有统计学意义(χ2=4.8623,P<0.05);(2)治疗组和对照组的6个月生存率分别为84.0%和55.2%(χ2=5.1725,P<0.05);12个月生存率分别为64.0%和34.5%(χ2=4.6855,P<0.05),两组差异有统计学意义(P<0.05);(3)两组的临床获益率和严重不良事件发生率差异无统计学意义(P>0.05)。结论:GP化疗联合适形放射治疗局部晚期胰腺癌,在提高生存率、延长生存期方面优于单纯GP化疗,但在临床获益率和严重不良事件发生率方面,二者无明显差异。
Objective To evaluate the therapeutic effect of combination chemotherapy of GP plus three dimensional conformal radiotherapy on patients with locally advanced pancreatic cancer. Methods Fifty-four patients with locally advanced pancreatic cancer were divided into combined therapy group （25 patients receiving combination chemotherapy of GP plus three dimensional conformal radiotherapy）, and control group（29 patients receiving combination chemotherapy of GP）. Results （1） The general remission rate（CR＋PR） was 68.0% in combined therapy group and 37.9% in control group respectively （Z2=4. 8623, P=0. 0275）. （2） The survival rates of 6 months and 12 months were 84. 0% and 64.0% in the former, and 55.2% and 34.5% in the latter respectively （Z2= 5. 1725, P=0.0229; Z2=4. 6855, P=0.0304）. （3）There was no statistic difference between two groups in clinical benefit response and total grave adverse events. Conclusion Combination chemotherapy of GP plus three dimensional conformal radiotherapy is be better than single combination chemotherapy of GP in elevating survival rate and elongating life time of patients with locally advanced pancreatic cancer, but there is no statistic difference in clinical benefit response and grave adverse events between these two methods.
出处
《实用诊断与治疗杂志》
2007年第6期421-422,424,共3页
Journal of Practical Diagnosis and Therapy
关键词
胰腺癌
放射治疗
化学治疗
Pancreatic cancerlradiotherapy
chemotherapy
