摘要
目的以鳖甲煎丸作为对照组，观察自制中成药消症软肝胶囊治疗乙型肝炎肝纤维化的临床疗效和毒副作用。方法选择120例乙型肝炎肝纤维化患者，随机分为两组：观察组和对照组，观察组服用消症软肝胶囊，对照组服用鳖甲煎丸，随访24周。治疗前、治疗中、治疗后查肝功能，肝纤指标，B超，血常规，肾功能，心电图。同时观察患者临床症状变化情况，并对结果进行统计学处理判定疗效。结果①治疗24周和随访24周时，治疗组临床症状好转率，肝功能及肝纤维化指标复常率均高于对照组。②两组总的不良事件发生率、药物相关的不良事件种类及各自的发生率差异无统计学意义。结论消症软肝胶囊治疗乙型肝炎肝纤维化疗效优于鳖甲煎丸，且无明显毒副作用，有待进一步探讨。
Objective To Compare the efficacy and safety of XiaoZhengRuanGan Capsule with BieJiaJianWan in treating Liver Fibrosis with Chronic Hepatitis B. Methods One hundred and twenty Liver Fibrosis patients with CHB（Chronic Hepatitis B） were randomly divided into two groups A and B, Group A took XiaoZhengRuanGan Capsule, Group B took BieJiaJianWan, both were followed up for 24 weeks. They were regularly monitored LFT （liver function test）,Blood analysis, BUN, CREA, HA, PIIINP, LN, ECG, Ultrasonic B throughout the course of treatment. Results （1）At the end of treatment and after followup, compared to the Group B, Group A showed better healing efficacy.（2）The overall incidence of adverse events （AEs） in the two groups were similar. Conclusions The efficacy and safety of XiaoZhengRuanGan Capsule for treating Liver Fibrosis patients seems to be better than that of BieJiaJianWan; however, further studies are needed to confirm it.
出处
《国际医药卫生导报》
2007年第10期90-92,共3页
International Medicine and Health Guidance News
关键词
肝纤维化
消症软肝胶囊
治疗
肝炎
乙肝
Liver Fibrosis XiaoZhengRuanGan Capsule Treatment
Hepatitis B Virus Chronic Hepatitis B.
