摘要
目的:观察氟中毒大鼠尿氟排泄情况,探讨维生素C、E不同剂量以及单独和/或联合使用对氟中毒大鼠尿氟排泄的影响。方法:将90只Wistar大鼠随机分为9组,每组10只,经饮水投氟建立氟中毒动物模型,并通过灌胃补充维生素C、E,分别于实验第5周、第10周和第15周收集24h尿液,采用氟离子选择性电极法测定尿氟含量。定期称体重,观察大鼠体重的变化。结果:随着染毒时间的延长大鼠尿氟的排出量逐渐增加,尿氟含量在染毒第15周>第10周>第5周(P<0.05)。补充维生素C和/或维生素E均可使大鼠尿氟含量显著增加。维生素C、E不同剂量组之间尿氟含量也有所不同,随着干预剂量的增加尿氟含量减少。结论:给予维生素C、E对氟中毒大鼠氟代谢有显著作用,可促进尿氟的排泄,阻断氟的吸收。维生素C、E在一定剂量范围内可拮抗氟的毒性作用,减轻氟中毒病情。
Objective： To study the influence of VitC and VitE on urinary fluoride excretion of the fluorosis rat. Methods： Ninety Wistar rats were divided into 9 groups randomly, produced the fluorosis animal model with high fluoride drinking water （150 rag/L）, and orally perfused jointly with VitC and/or VitE, collected 24 hours urine to test the urinary fluoride content by fluorine ion selective electrode method on the 5th week, 10th week and the 15th week respectively. Result. VitC, VitE could increase the concentration of fluoride in urine of rats. Conclusion： The effect of VitC and VitE to the fluorine metabolism of fluorosis rat is remarkable, they may promote the excretion of urinary fluoride, inhibit the absorption of fluoride. These show that a specific amounts of VitC and/or VitE may counteract the toxic effect of fluoride, relieve the fluorosis condition.
出处
《新疆医科大学学报》
CAS
2007年第4期352-353,357,共3页
Journal of Xinjiang Medical University
基金
新疆维吾尔自治区高校科研计划项目(XJEDU2004S17)
关键词
氟中毒
维生素C、E
尿氟
fluorosis
Vitamin C
Vitamin E
urine fluoride
