摘要
背景与目的:18F-脱氧葡萄糖(fluorine-18 fluorodeoxyglucose,18F-FDG)PET/CT显像可明显提高肺癌、食管癌等多种肿瘤的诊断、分期与疗效监测的准确性,有助于更准确地制定治疗方案。本研究探讨全身18F-FDG PET/CT显像在鼻咽癌首次分期、再分期及疗效监测中的临床应用价值。方法:回顾性分析澳大利亚Peter MacCallum肿瘤中心2002年2月至2005年12月43例鼻咽癌患者的18F-FDG PET/CT全身扫描报告,根据临床资料、病理结果及临床随访结果,计算18F-FDG PET/CT与传统影像学检查CT、MRI的准确性、特异性、灵敏度、阳性预测值与阴性预测值,并对结果进行比较和分析。结果:18F-FDG PET/CT诊断鼻咽癌总的准确率、敏感性、特异性、阳性预测值与阴性预测值分别为95.3%、100.0%、85.7%、93.8%、100.0%,传统影像学检查CT、MRI分别为65.5%、79.4%、64.7%、81.8%、57.9%。18F-FDGPET/CT诊断结果使2例首次分期、7例再分期患者治疗方案得到改变,并影响1例首次分期和3例再分期患者治疗方案的制定;在疗效监测组中,指导医生修改治疗方案共11例(其中5例为原则性的修改)。18F-FDG PET/CT检测到2例第二原发肿瘤,1例是甲状腺癌,1例是低度恶性胃癌。结论:18F-FDG PET/CT全身显像对鼻咽癌N、M分期与疗效监测的临床作用可能优于CT、MR检查。
BACKGROUND ＆ OBJECTiVE：Fluorine-18 fluorodeoxyglucose （^18SF-FDG） PET/CT could increase the accuracy of diagnosis, staging, and treatment effectiveness monitoring of many malignant diseases, such as lung cancer and esophageal cancer. This study was to evaluate the clinical application of ^18SF-FDG PET/CT to the staging, restaging, and treatment effectiveness monitoring of nasopharygeal carcinoma （NPC）. METHODS： The reports of whole body ^18F-FDG PET/CT scans, performed from Feb. 2002 to Dec. 2005 on 43 NPC patients （26 men and 17 women with median age of 52 years） in Peter MacCallum Cancer Center, were reviewed. The final diagnoses were made according to medical records, pathologic reports and follow-up information. The accuracy, specificity, sensitivity, positive predictive value （PPV）, and negative predictive value （NPV） of ^18F-FDG PET/CT, CT and MRI were calculated and analyzed. RESULTS： The accuracy, specificity, sensitivity, PPV, and NPV of ^18SF-FDG PET/CT were 95.3%, 100.0%, 85.7%, 93.8%, and 100.0%, respectively; those of CT and MRI were 65.5%, 79.4%, 64.7%, 81.8%, and 57.9%, respectively. The results of ^18SF-FDG PET/CT led to changes in the medical management of 2 staged patients, and 7 restaged patients and 5 patients in monitoring group. ^18F-FDG PET/CT scan affected the therapy plan of 3 restaged patients and 11 patients in monitoring group. Two cases of second primary malignancies （1 case of thyroid carcinoma and 1 case of low grade gastric carcinoma） were detected by ^18SF-FDG PET/CT scan. CONCLUSION; ^18F-FDG PET/CT is better than conventional imaging in N and M staging and treatment effectiveness monitoring of NPC.
出处
《癌症》
SCIE
CAS
CSCD
北大核心
2007年第6期638-642,共5页
Chinese Journal of Cancer
关键词
鼻咽肿瘤
肿瘤分期
体层摄影术
发射型计算机
体层摄影术
X线计算机
脱氧葡萄糖
诊断
疗效监测
Nasopharygeal neoplasm
Neoplasm staging
Tomography,emission computed
Tomography, X-ray computed
Deoxyglucose
Diagnosis
Treatment effectiveness monitoring
