摘要
目的探讨新辅助化疗对乳腺癌ER、PR、C-erbB-2、P53、Ki-67表达的影响。方法通过免疫组化检测化疗前后38例乳腺癌ER、PR、C-erbB-2、P53、Ki-67的表达。结果新辅助化疗前后ER、PR状态各有9例发生变化,C-erbB-2状态各有8例发生变化,P53状态各有10例发生变化,比较差异均无统计学意义;Ki-67状态有17例发生改变,比较差异有统计学意义。结论新辅助化疗对ER、PR、C-erbB-2、P53表达状态无显著影响,而能显著降低Ki-67的表达。
Objective To study the effect of neoadjuvant chemotherapy on expressions of ER, PR.C-erbB-2,P53 and Ki-67 in breast cancer. Methods Expressions of ER,PR,C-erbB-2,P53,Ki- 67 of 38 patients with breast cancer were measured by immunohistochemistry before and after neoadjuvant chemotherapy. Results Among all the 38 cases, the status of ER, PR, C-erbB-2 and P53 had change only in 9,9,8 and 10 cases respectively. There was no statistical difference significantly before and after neoadjuvant chemotherapy. The status of ki-67 had change in 17 cases. And the difference had statistical significance before and after neoadjuvant chemotherapy. Conclusion Neoadjuvant chemo- therapy has no signifieant influence on status of ER, PR, C-erbB-2 and P53, but it can reduce the cxpression of ki-67 significantly.
出处
《岭南现代临床外科》
2007年第2期111-113,共3页
Lingnan Modern Clinics in Surgery
