摘要
目的：探讨趋化因子受体4（CXCR4）和血管内皮生长因子C（VEGF-C）在人胃癌组织中的表达及其与淋巴结转移的关系。方法：选择86例胃癌标本,应用免疫组织化学染色方法,检测CXCR4和VEGF-C在人胃癌组织中的表达,同时对其与临床病理参数的关系进行统计学分析。结果：CXCR4在胃癌组织中的阳性表达率为66.28%,其中淋巴结转移组表达率为83.33%,无淋巴结转移组表达率为23.26%,差异非常显著（P〈0.01）。VEGF-C在胃癌组织中的阳性表达率为73.26%,其中淋巴结转移组织表达率为91.67%,无淋巴结转移组织表达率为5.81%,差异非常显著（P〈0.01）。而且,CXCR4阳性表达与VEGF-C阳性表达呈显著正相关（γ=0.498,P〈0.05）。胃癌CXCR4和VEGF-C的表达水平与肿瘤细胞淋巴结转移密切相关,而与病人的组织学类型、分化程度、肿瘤浸润深度和淋巴结转移等有相关性（P〈0.01-0.05）。结论：CXCR4和VEGF-C的表达可作为评估胃癌病人淋巴道转移的一个观测指标。
Objective：To investigate the relationship of the expressions of chemokine CXC receptor 4（CXCR4） and vascular endothelial growth factor C （VEGF- C） with lymph node metastasis in gastric cancer. Methods： Immuohistochemistry was used to detect the expressions of CXCR4 and VEGF - C in 86 samples of human gastric cancer. The relationship between CXCR4 and VEGF - C expressions and the clinical pathological diameters was statistically analyzed. Results： The total positive rate of CXCR4 expression in these samples was 66. 28%, and it was higher in the cases with lymph node metastasis than that without lymph node metastasis（S3.33% vs 23. 26%, P〈0. 01）. Meanwhile, the total positive rate of VEGF - C expression was 73. 26%, and was higher in the cases with lymph node metastasis than that without lymph node metastasis （91.67% vs 5. 81%, P〈0. 01）. The positive expression of CXCR4 was consistent with the positive expression of VEGF - C（y= 0. 498, P〈0. 05）, and the expression levels of CXCR4 and VEGF - C were closely correlated with histological type, cellular differentiation, invasion depth and lymph node metastasis （P〈 0. 01 - 0. 05 ）. Conclusion： CXCR4 and VEGF-C expressions may become predictors for the lymphatic metastasis of gastric cancer.
出处
《西南国防医药》
CAS
2007年第3期285-288,共4页
Medical Journal of National Defending Forces in Southwest China
关键词
趋化因子受体CXCR4
血管内皮生长因子C
胃癌
淋巴结转移
chemokine receptor
CXCR4
vascular endothelial growth factor C
gastric carcinoma
lymphatic metastasis
correlation
