期刊文献+

内皮抑素概论及抗肺癌作用 被引量:4

Review on endostatin and related effecacy on lung cancer
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摘要 肿瘤的生长转移与肿瘤血管生成密切相关,抗血管生成是治疗肿瘤的新策略。内皮抑素是特异性的血管内皮细胞生长抑制因子,能显著抑制肿瘤血管增生并诱导肿瘤细胞凋亡。内皮抑素的抗血管生成治疗和血管靶向基因治疗,为治疗肺癌提供了广阔前景。 The growth and metastasis of tumor are correlated with angiogenesis.Antiangiogenesis is a new tactic in treating tumor.Endostatin can specifically inhibit tumor endothelial cell proliferation,angiogenesis and induce cell apoptosis.The therapy of antiangiogenesis and target gene offer a broad clinic prospect for lung cancer.
出处 《药学与临床研究》 2007年第3期184-186,共3页 Pharmaceutical and Clinical Research
关键词 内皮抑素 血管生成 肺癌 Endostatin Angiogenesis Lung cancer
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参考文献15

  • 1O'Reilly MS,Boehm T,Shing Y,et al.J.Endostatin:an endogenous inhibitor of angiogenesis and tumor growth[J].Cell,1997,88(2):277-285.
  • 2Hohenester E,Sasaki T,Mann K,et al.Variable zinc coordination in endostatin[J].J Mol Biol,2000,297(1):1-6.
  • 3Zatterstrom UK,Felbor U,Fukai N,et al.Collagen XⅧ/endostatin structure and functional role in angiogenesis[J].Cell Struct Funct,2000,25(2):97-101.
  • 4Wen W,Moses MA,Wiederschain D,et al.The generation of endostatin is mediated by elastase[J].Cancer Res,1999,59(24):6052-6056.
  • 5Ergun S,Kilic N,Wurmbach JH,et al.Endostatin inhibits angiogenesis by stabilization of newly formed endothelial tubes[J].Angiogenesis,2001,4(3):193-206.
  • 6Dhanabal M,Ramchandran R,Waterman MJ,et al.Endostatin induces endothelial cell apoptosis[J].J Biol Chem,1999,274(17):11721-11726.
  • 7Yamaguchi N,Anand-Apte B,Lee M,et al.Endostatin inhibits VEGF-induced endothelial cell migration and tumor growth independently of zinc banding[J].EMBO J,1999,18(16):4414-4423.
  • 8Lee SJ,Jang JW,Kim YM,et al.Endostatin binds to the catalytic domain of matrix metalloproteinase-2[J].FEBS Lett,2002,519(1-3):147-152.
  • 9张广美,王淑静,任明华,徐建永,刘远莉,陶占华,李冀宏,刘兴汉.重组人内皮抑素的纯化及抗肿瘤活性研究[J].中国肿瘤,2005,14(2):122-125. 被引量:4
  • 10Luo X,Slater JM,Gridley DS.Enhancement of radiation effects by Pxlg-mEndo in a lung carcinoma model.[J].Int J Radiat Oncol Biol Phys,2005,63(2):553-564.

二级参考文献39

  • 1杨林,王金万,汤仲明,刘秀文,黄镜,李树婷,董英,张和平,薛岚,储大同,孙燕.重组人血管内皮抑制素Ⅰ期临床研究[J].中国新药杂志,2004,13(6):548-553. 被引量:154
  • 2周清华,孙燕.加强我国肺癌分子靶向治疗基础和临床研究[J].中国肺癌杂志,2004,7(4):267-269. 被引量:51
  • 3杨林,王金万,崔成旭,黄镜,张和平,李树亭,孙燕.重组人血管内皮抑制素YH-16联合用药治疗晚期非小细胞肺癌的多中心Ⅱ期临床试验[J].中国新药杂志,2005,14(2):204-207. 被引量:116
  • 4Hahnfeldt P,Panigrahy D,Folkman J,et al.Tumor development under angiogenic signaling:a dynamical theory of tumor growth,treatment,response,andpostvascular dormancy[J]. Cancer Res, 1999,59(19):4770-4775.
  • 5O'Reilly MS,Boehm T, Shing Y,et al. Endostatin:An endogenous inhibitor of angiogenesis and tumor growth [J].Cell, 1997,88:277-285.
  • 6Capillo M,Mancuso P,Gobbi A,et al. Continuous infusion of endostatin inhibits,differentiation,mobilization,and clonogenic potential of endothelial cell progenitors[J].Clin Cancer Res, 2003,9(1):377-382.
  • 7Davis DW,Shen Y,Mullani NA,et al. Quantitative analysis of biomarkers defines an optimal biological dose for recombinant human endostatin in primary human tumors [J].Clin Cancer Res,2004,1(10):33-42.
  • 8Dhanabal M,Ramchandran R,Volk R,et al. Endostatin:yeast production,mutants,and antitumor effect in renal cell carcinoma [J].Cancer Res, 1999, 59:189-197.
  • 9Cohen J.Behind the headlines of endostatin's ups and downs [J].Science, 1999, 283(5406): 1250-1251.
  • 10Sean Tedjarati,Cheryl H Baker, Sachin Apte,et al.Synergistic therapy of human ovarian carcinoma implanted orthotopically in nude mice by optimal biological dose of pegylated interferon combined with paclitaxel [J].Clin Cancer Res,2002,8: 2413-2422.

共引文献627

同被引文献36

  • 1王金万,孙燕,刘永煜,于起涛,张沂平,李凯,朱允中,周清华,侯梅,管忠震,李维廉,庄武,王东林,梁后杰,秦凤展,卢辉山,刘晓晴,孙红,张燕军,王杰军,罗素霞,杨瑞合,涂远荣,王秀问,宋恕平,周静敏,游丽芬,王竞,姚晨.重组人血管内皮抑素联合NP方案治疗晚期NSCLC随机、双盲、对照、多中心Ⅲ期临床研究[J].中国肺癌杂志,2005,8(4):283-290. 被引量:626
  • 2于水静,张树英,邱萌,易成,黄英,王树人.环磷酰胺和紫杉醇联合化疗诱导小鼠Lewis肺癌细胞的凋亡[J].华西药学杂志,2006,21(1):43-44. 被引量:2
  • 3张兵,徐爱晖.化疗与手术对肺癌患者血清endostatin水平影响的初步观察[J].肿瘤,2006,26(6):563-565. 被引量:4
  • 4FOLKMAN J.Tumor angiogenesis:therapeutic implication[J].N Engl J Med,1971,285(3):1182-1186.
  • 5TANAKA T,KONNO H,BABA S,et al.Prevention of hepatic and peritoneal metastases by the angiogenesis inhibitor FR-118487 after removal of growing tumor in mice[J].Jpn J Cancer Res,2001,92(1):88-94.
  • 6FOLKMAN J.Role of angiogenesis in tumor growth and metastasis[J].Semin Oncol,2002,29(6):15-18.
  • 7NAUMOV G N,FOLKMAN J,STRAUME O.Tumor dormancy due to failure of angiogenesis:role of the microenvironment[J].Clin Exp Metastasis,2009,26(1):51-60.
  • 8DONG Z,KUMAR R,YANG X,et al.Macrophage-derived metal-loelastase is responsible for the generation of angiostatin in Lewis lung carcinoma[J].Cell,1997,88 (6):801-810.
  • 9CARRILLO E,CASO E,SA'NCHEZ I,et al.Prognostic significance of the expression of vascular endothelial growth factors A,B,C,and D and their receptors R1,R2,and R3 in patients with non-small cell lung cancer[J].Cancer,2009,15(4):1701-1712.
  • 10FOLKMAN J.Antiangiogenesis in cancer therapy-endostatin and its mechanisms of action[J].Cell Res,2006,312(2):594-607.

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