期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

肝靶向甘草次酸修饰的壳聚糖纳米粒子的合成和表征 被引量：16

Synthesis and Characterization of Chitosan Nanoparticles Modified by Glycyrrhetinic Acid as a Liver Targeting Drug Carrier
下载PDF
导出
摘要 Chitosan derivative with glycyrrhetinic acid(GA),which was accumulated specifically in liver,was synthesized.By ion-crosslinking of TPP in GA-CTS solution,GA-CTS-TPP complex nanoparticles were obtained.The physicochemical properties of these nanoparticles were investigated by using TEM and DLS.The experiment in vitro BSA entrapped was studied.GA-CTS-TPP nanoparticles are well dispersed and stable in aqueous solution in 14 months. Chitosan derivative with glycyrrhetinic acid （GA）, which was accumulated specifically in liver, was synthesized. By ion-crosslinking of TPP in GA-CTS solution, GA-CTS-TPP complex nanoparticles were obtained. The physicochemical properties of these nanoparticles were investigated by using TEM and DLS. The experiment in vitro BSA entrapped was studied. GA-CTS-TPP nanoparticles are well dispersed and stable in aqueous solution in 14 months.
作者 查瑞涛 贺晓婷 杜田 袁直
机构地区 南开大学高分子化学研究所功能高分子材料教育部重点实验室
出处 《高等学校化学学报》 SCIE EI CAS CSCD 北大核心 2007年第6期1098-1100,共3页 Chemical Journal of Chinese Universities
基金 教育部天津大学-南开大学科技合作基金 天津市自然科学基金(批准号:07JCZDJC00700)资助
关键词 甘草次酸 壳聚糖 肝靶向 Glycyrrhetinic acid Chitosan Liver targeting
分类号 O625 [理学—有机化学]
  • 相关文献

参考文献6

  • 1Kumar V.,Banker G.S..Targeted Oriented Drug Delivery Systems[A].Banker G.S.,Rhodes C.T.Eds.;Modern Pharmaceutics,3ed.,Vol.72[M],New York:Marcel Dekker,1996:611-680
  • 2Wang Z.,Nishioka M.,Kurosaki Y.,et al..Biol.Pharm.Bull.[J],1995,18(9):1238-1241
  • 3YANGShan-Mai(杨山麦) ZHOUFang-Cheng(周方成) GUYun-Ti(顾云娣).中华肝脏病杂志,1999,7(1):27-29.
  • 4Negishi M.,Irie A.,Nagataa N.,et al..Biochimica et Biophysica Acta(BBA)Biomembranes[J],1991,1066(1):77-82
  • 5Sayoko O.,Hideki T.,Hiroshi K..Biol.Pharm.Bull.[J],1994,17(7):940-943
  • 6郑建华,刘朝武,包德才,赵燕军,马小军.克拉霉素漂浮-生物粘附微囊的制备及性能研究[J].高等学校化学学报,2006,27(6):1182-1185. 被引量：4

二级参考文献10

  • 1于炜婷,雄鹰,刘袖洞,王为,谢威扬,马小军.海藻酸钠-壳聚糖微胶囊作为肠道内生化微反应器的研究[J].高等学校化学学报,2004,25(7):1381-1383. 被引量：16
  • 2DIAOYong(刁勇) TUXi-De(屠锡德).药学学报,1991,26:695-695.
  • 3Murata Y. , Kofuji K., Kawashima S.. J. Biomater Sci. Polym. Ed. [J], 2003, 14:581-588
  • 4Francesco P., Asghar Q., Lea M. et al.. Helicobacter[J], 2003, 8:53-60
  • 5Malfertheiner P. , Megraud F. , Oorain C. et al.. Aliment Pharmacol Ther. [ J], 2002, 16:167-180
  • 6Pharmacopoeia Commission of People’s Republic of China(国家药典委员会)．Pharmacopoeia of People’s Republic of China(中华人民共和国药典)[M]，Beijing：Chemical Industry Press，2000：271
  • 7Umamaheswari R. B. , Jain S. , Jain N. K.. Drug Del. [J], 2003, 10:151-160
  • 8Akiyama Y. , Nagahara N. , Kashihara T. et al.. Pharm. Res. [J] , 1995, 12:397-405
  • 9Liu Z. P. , Lu W. Y. , Qian L. S. et al.. J. Control Release[J] , 2005, 102:135-144
  • 10He P. , Davis S. S. , Illum L.. Int. J. Pharm. [J] , 1998, 166:75-88

共引文献3

同被引文献194

引证文献16

二级引证文献92

高等学校化学学报
2007年 第6期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部