摘要
目的:探讨Ⅰ期细支气管肺泡癌(bronchioloalveolar carcinoma,BAC)和腺癌的临床特点及预后因素。方法:对于在我院接受手术的67例Ⅰ期细支气管肺泡癌和190例Ⅰ期腺癌的临床资料进行对比分析。结果:Ⅰ期BAC和腺癌的发生在性别(P=0·005)和是否吸烟(P=0·015)差异有统计学意义。影像学表现方面,二者出现分叶征(P=0·024)、空泡征(P=0·014)和磨玻璃征(P=0·000)的概率差异有统计学意义。Ⅰ期BAC和腺癌术后5年生存率分别为68·0%、46·0%,差异有统计学意义,P=0·0043。BAC男性患者术后5年生存率高于女性(P=0·035),而肺腺癌女性患者术后5年生存率高于男性(P=0·027);手术方式与BAC预后无关联,而腺癌行肺叶切除术的患者5年生存率高于肺段切除术的患者(P=0·040);吸烟与两者的预后均无关联。结论:Ⅰ期BAC女性患者多于男性,与吸烟无明显相关性,标准术式为肺叶切除+淋巴结清除术,预后优于腺癌,且男性优于女性。
OBJECTIVE：To compare the clinic characteristics and prognostic factors in patients with stage I bronchioloalveolar carcinoma （BAC） and adenocarcinoma of the lung. METHODS： Clinic data of 257 inpatient cases with stage I BAC and adenocarcinoma in The Cancer Hospital of Tianjin Medical University, were retrospectively reviewed. We made a comparion between the two groups. RESULTS： Stage Ⅰ BAC and adenocarcinoma have apparent differences in gender （P = 0. 005） and smoking （ P = 0. 015 ）, and they have different imaging characteristics. The 5-year survival rate of Stage Ⅰ BAC （68. 0%） was higher than that of adenocarcinoma （46. 0%）,P=0. 0043. The 5-year survival rate of male was higher than female with BAC （P=0. 035）,while the 5-year survival rate of female was higher than male with adenocarcinoma, P = 0. 027. The surgical methods have no impact on the 5-year survival rate of Stage Ⅰ BAC, while the surgical methods have apparent impact on the 5-year survival rate of Stage Ⅰ adenocarcinoma, P = 0. 040. Smoking has no impact on the 5-year survival rate of Stage Ⅰ BAC and adenocarcinoma. CONCLUSIONS： Stage Ⅰ bronchioloalveolar carcinoma is more likely to occure in female. No obvious relation is found with smoking. Lobectomy is performed as standard method in its surgical treatment. The prognosis with BAC is superior to adenocarcinoma, and the prognosis of male is superior to female.
出处
《中华肿瘤防治杂志》
CAS
2007年第12期939-941,共3页
Chinese Journal of Cancer Prevention and Treatment
关键词
腺癌
细支气管肺泡
临床对照研究
预后
adenocarcinoma, bronchiolo-alveolar
case-control studies
prognosis
