摘要
提出一种基于旋转偏振角的新的偏振光成像方法:改变入射线偏振光偏振角和检偏角,采集样品图像系列,总结出背向散射光2个正交偏振分量的光强差关于入射线偏振光偏振角和检偏角的函数关系式.通过对模拟散射介质,猪肉脂肪,猪肉骨骼肌和牛肉骨骼肌等样品进行实验,论证了偏振差函数式中各个参数与样品光学特性之间的联系,并从中提取出2个相互独立的参数,分别表征样品的纤维方向角和光学各向异性度,从而实现对样品浅表层光学特性进行定量测量.和普通光强图像相比,用这些独立的光学信息生成不同基色的图像,能更直观明了地区分组织结构差异,具有潜在的临床医学应用价值,如成为一种皮肤疾病、皮肤损伤的检测方法.
A novel polarized light reflective imaging method using rotating linearly polarized light was demonstrated. By varying the incident and detection polarization angles in a fixed increments, a series of images corresponding to different combinations of incident and detection polarizations are recorded. Intensity difference corresponding to orthogonal detection polarizations are calculated pixel by pixel as a function of incident and detection polarization angle and fitted to an empirical formula. The fittings result in a set of parameters. Using various tissue samples and intralipid as phantom, the correlation between these parameters and the optical characters of the sample, such as scattering coefficient, anisotropy and orientation of macro structure was demonstrated. Images based on theses parameters may find clinical applications in diagnosis of skin diseases or assessment of skin damages.
出处
《生物化学与生物物理进展》
SCIE
CAS
CSCD
北大核心
2007年第6期659-663,共5页
Progress In Biochemistry and Biophysics
基金
国家自然科学基金面上项目(60578003)
国家重点基础研究发展计划(973)(2006CB70570).~~
关键词
偏振成像
线偏振
偏振角
各向异性度
polarized imaging, linear polarization, polarization angle, anisotropic
