摘要
目的探讨肝硬化患者红细胞免疫功能的变化及其它脂质过氧化的关系。方法应用红细胞酵母花环法测定了38例肝硬化患者红细胞免疫功能和化学比色法测定血浆丙二醛(MDA)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-PX)含量并与30名正常健康人作比较。结果肝硬化患者RBC-IC花环率和MDA水平明显的升高(P<0.01),而RBC-C3b,SOD、GSH-PX、SOD/MDA明显低于正常(P<0.01),相关分析显示RBC-C3b花环与MDA呈显著的负相关(r=-0.4028,P<0.05)。RBC-ICR与MDA呈正相关(r=0.6184,P<0.01)。结论肝硬化病人红细胞免疫粘附功能的降低,与活性氧代谢紊乱密切相关。
Objective To study the red blood cell immunity and the relationship between red blood cell immu- nity and lipid peroxidation （lpo）with liver cirrhosis . Method The red blood cell C3b receptor （RBC-C3b） and red blood cell immunol complex rosette（RBC-ICR） were measured in 38 patients with liver cirrhosis and 30 normal controls and the levels of malondialdohyde （MDA）. superoxidase （SOD） and glutathione peroxidase （GSH-PX） were measured by chemical inrimetry. Results RBC-ICR and MDA levels were significantly higher in patients with liver cirrhosis than those in normal controls （P〈0.01）. while RBC-C3b. SOD. GSH-PX. SOD/MDA ratio were significantly lower in patients with liver cirrhosis than those in normal controls（P〈0.01）. On the contrary the content of MDA was significantly increased . RBC-ICR was positively correlated with MDA. Conclusions The lower red cell immune adhesion function is closed associated with the lipid peroxidation disturbance in liver cirrhosis.
出处
《医学动物防制》
2007年第5期344-345,共2页
Journal of Medical Pest Control
关键词
肝硬化
丙二醛
超氧化物歧化酶
谷胱甘肽过氧化物酶
红细胞免疫
Liver cirrhosis
Malondialdohyde（MDA）
Superoxide dismurase（SOD）
Glutarhione peroxidase （GSH-PX）
Red blood cell immunity.
