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司他夫定的合成 被引量：1

Synthesis of Stavudine
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摘要 以2'-溴-3',5'-二乙酰基胸苷为原料,经Zn/AcOH催化的消除反应、水解脱乙酰基制得抗病毒药司他夫定,总收率约60%。 Stavudine, a HIV reverse transcriptase inhibitor, was synthesized from 2＇-bromo-3＇,5＇-diacetyl thymidine by elimination in the presence of Zn/AcOH followed by deacetylation with an overall yield of about 60 %.
作者 姜迅知 鞠玻
机构地区 浙江中药与天然药物研究院
出处 《中国医药工业杂志》 CAS CSCD 北大核心 2007年第6期403-404,共2页 Chinese Journal of Pharmaceuticals
关键词 司他夫定 HIV逆转录酶抑制剂 合成 stavudine HIV reverse transcriptase inhibitor synthesis
分类号 R978.7 [医药卫生—药品]
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参考文献7

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二级参考文献22

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共引文献29

同被引文献30

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引证文献1

中国医药工业杂志
2007年 第6期

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