摘要
目的:研究盐酸罗匹尼罗片剂在健康人体的药动学。方法:以液相色谱-串联质谱分析法(LC-MS-MS)测定12名健康志愿受试者单次口服1.0mg罗匹尼罗片后36h内不同时间的血药浓度,采用DAS2.0.1软件计算给药后的药动学参数。结果:12名健康受试者单次空腹口服1.0mg罗匹尼罗片后,其主要药动学参数t1/2为(6.7±1.1)h;tmax为(1.4±0.5)h;Cmax为(1.6±0.5)μg·L-1;AUC0-t为(10.8±3.1)μg·h·L-1,AUC0-∞为(11.1±3.2)μg·h·L-1,MRT为(8.5±1.1)h,CL/F为(95.8±21.9)L·h-1,Vd/F为(916±256)L。结论:本方法灵敏、快速、准确、选择性强,可较好地满足罗匹尼罗的药动学研究,为临床用药提供依据。
OBJECTIVE To study pharmacokinetics of ropinirole tablets in healthy volunteers. METHODS The plasma samples were collected at different time points within 36 hours in 12 healthy volunteers after single-dose orally administration 1 rng ropinirole. Plasma drug concentrations detected by LC-MS-MS, and then the DAS 2. 0. 1 software was used to analyze the pharmacokinetics parameters. RESULTS The main pharmacokinetics of ropinirole group were as follows., t1/2 （6. 7 ± 1.1 ） h; tmax（1.4±0. 5）h; Cmax（1.6 ± 0. 5）μg. L^-1 ） AUC0-t（10. 8 ±3.1）μg.h.L^-1 , AUC0-∞ （11.1 ± 3.2）μg.h.L^-1 ） MRT （8. 5 ± 1.1） h, CL/F（95.8 ±21.9）L.h^-1 , Vd/F （916±256）L. CONCLUSION The method is preferable to apply to the pharmacokinetics research of ropinirole. The study is useful for clinical therapy.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2007年第6期729-731,共3页
Chinese Journal of Hospital Pharmacy
