摘要
目的:麻醉药物对硬膜外阻滞利多卡因药动学影响进行研究。方法:分别对12例腹部及下肢手术患者硬膜外阻滞加全麻和腰麻—硬膜外联合阻滞麻醉后的药动学参数进行研究和评价,采用荧光偏振免疫方法(FPIA)测定血中利多卡因浓度,3P97程序进行药动学参数线性拟合,t检验比较组间差异。结果:硬膜外阻滞加全麻和腰麻—硬膜外联合阻滞注药后,血药浓度达峰时间分别为(8.4±0.6)min和(9.0±0.6)min(P>0.05),血药峰值分别为(2.16±0.25)mg·L-1和(2.02±0.20)mg·L-1(P>0.05),吸收速率常数分别为(19.3±4.4)h-1和(19.4±4.8)h-1(P>0.05),消除半衰期分别为(3.3±1.7)h和(2.6±0.6)h(P>0.05)。结论:麻醉药物对硬膜外阻滞利多卡因药动学无显著影响,可以安全使用。
OBJECTIVE The study elucidated the regular pattern of lidocaine in absorption, distribution and elimination after it entered epidural cava when CSE was performed. The study investigated the influences of intravenous anesthetics on the pharmacokineties of lidocaine in order to provide data for clinic, which applied safely sedative and narcotic before operation METHODS Twelve adult patients scheduled for elective major abdominal and orthopedic surgical procedures were included in this study, they were randomly allocated into two groups. A combination of intravenous anesthesia （TIVA） and epidural anesthesia was applied to group Ⅰ and epidural block was applied to group Ⅱ. The blood samples were collected after anesthesia in the sequence of 5,10,15,30,60,90,120,150,180,360,480 min. lidocaine concentration in serum was determined with fluorescence polarization immunoassay （FPIA）. Data were handled with the program 3P97. The effects of intravenous anesthetics on the pharmacokinetics of lidocaine were investigated. RESULTS The pharmacokinetic parameters of lidocaine in the two groups after epidural administration of lidocaine are as follows： tmax ： （8. 4 ± 0. 6） min and （9. 0 ± 0.6） min（P〉0. 05）, Cmax ： （2. 16 ± 0. 25） mg.L^-1 and （2. 02 ± 0. 20） mg.L^-1 （P〉0.05）, t1/2β ： （3. 3± 1. 7） h^-1 and （2. 6± 0. 6） h^-1 （P〉0. 05）respectively. CONCLUSION This study showed intravenous anesthetics has no significant effects on the pharmacokinetics of lidocaine during epidural block.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2007年第6期786-788,共3页
Chinese Journal of Hospital Pharmacy
