摘要
目的探讨血管内皮生长因子(VEGF)、基质金属蛋白酶(MMP-7)表达与大肠癌进展及预后的关系。方法采用免疫组SP法检测81例大肠癌(CC)中VEGF及MMP-7的表达。结果VEGF的表达与大肠癌的浸润深度、淋巴结转移、远处转移、Dukes分期呈正相关。而MMP-7表达与大肠癌的淋巴结转移、远处转移、Dukes分期呈正相关,黏液癌中表达明显高于高分化腺癌,年龄<60岁的大肠癌患者MMP-7表达显著强于≥60岁者。VEGF与MMP-7表达呈正相关。结论MMP-7、VEGF促进了大肠癌组织的生长和转移,具有协同作用,可作为大肠癌的预后评估因子,联合检测以上指标对评估大肠癌的预后可能更准确。降低MMP-7、VEGF的表达和活性可能成为抗肿瘤转移治疗的一个新途径。
Objective To explore the relationships between VEGF, MMP-7 expression and progress , prognosis of colorectal Carcinoma. Methods SP immunohistochemical staining was used to examine expressions of VEGF, MMP-7 among 81 cases of colorectal carcinoma paraffin-embedded specimens. Rank sum test was used to analyze the expressions of VEGF, MMP-7. Results The expression of VEGF in eoloreetal carcinoma was positively correlated with depth of invasion（P〈0.01 ）, lymph node metastasis （P〈0. 01 ）, distant metastasis（P〈0. 01 ）, Dukes stage. MMP-7 expression in colorectal carcinoma was also positively correlated with lymph node rnetastasis（P〈0.05）, distant metastasis（P〈0. 01 ）, Dukes＇ stage. Expression of MMP-7 in mucous group was higher than that in high differentiation group （P〈 0. 01 ）. The MMP-7 expression in patients aged below 60y was stronger than that in over 60y and 60y （P 〈0. 05）. Positive relationship appeared between VEGE and MMP-7. Conclusion VEGF, MMP-7 may improve the growth and metastasis of colorectal carcinoma. They could be prognostic factor of colorectal carcinoma. Decreasing the expression and activity of VEGF and MMP-7 might be a new pathway for the treatment of colorectal carcinoma.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
2007年第6期442-445,I0004,共5页
Cancer Research on Prevention and Treatment
基金
河北承德市科技局资助项目(20031018)
河北省科技厅指导性课题(032761138)
