摘要
应用克隆化鼠甲状腺细胞株（FRTL－5）的cAMP反应检测了17例正常人、18例甲状腺功能正常甲亢（EG）、29例未治甲亢（HG）的血清TSAb水平。正常组为（94．5±441）％（n＝17，x±s），全部TSAb阴性；EG组为（465±486．7）％（n=18），其中14例（77．8％）为阳性；HG组为（2205．1±3053）％（n=29），其中27例（93．1％）为阳性。EG组同HG组比较，阳性率无差异。但TSAb活性较HG级低（P＜0．005）。结果表明，EG组患者存在自身免疫异常。因此TSAb的测定对EG的诊断具有重要意义。
TSAb were measured by using cultured FRTL-5 cells incubated with crude immunoglobin fractions sedimented from serum with PEG (MW 4000). cAMP reIeased in the medium might represent TSAb activity. cAMP was found in 77. 8% (14/18 ) and 93. 1% (27/29) of the patients with euthyroid (EG) and hyperthyroid (HG) Graves' disease respectively. The normal controls were not cAMP peitive. The results suggest that EG is similar to HG as an autoimmune disease. The assay for TSAb can be useful in EG diagnosis.
出处
《中国现代医学杂志》
CAS
CSCD
1997年第4期6-6,19,共2页
China Journal of Modern Medicine
关键词
TSAb
甲状腺功能正常
甲状腺机能亢进
沉淀
FRTL-5 cells
cAMP
TSAb
Euthyroid Graves' disease
Hyperthyroid Graves' disease
