摘要
目的观察重组(酵母)基因乙肝疫苗(简称乙肝疫苗)接种的免疫效果,为提高预防接种的阳转率提供依据。方法对560名新生采用0、1、6月方案,预防接种乙肝疫苗后1个月检测抗-HBs阴性者,采用0、1、2月方案再次进行免疫,1个月后检测抗-HBs仍阴性者,采取增加剂量(10μg/ml)再按0、1、2月方案进行接种,观察免疫接种的效果。结果初次接种一个月后,抗-HBs阳转率为77.5%,男性与女性阳转率差别不大(P>0.05);对抗-HBs阴性者,再次接种乙肝疫苗后抗-HBs阳转率为80.16%,女性高于男性(P<0.05);对抗-HBs仍然阴性者,采取增加剂量第3次接种,阳转率为100%。结论初次全程免疫后未产生免疫应答者,经再次和第3次免疫接种后抗-HBs阳转率可达100%。
Objective To observe the immune effect of immunzation with the recombined yeast gene hepatitis B vaccine （HBV） among those who did not well respond to the initial vaccination and to provide evidences for reasonable secondary immunization with hepatitis B vaccine. Methods A total of 560 college freshmen were immunized with hepatitis B vaccine by using 0 -, l -, and 6 - month schemes respectively, and then inspected the effects of immunization. Results One month after the primary full- access immunization, the anti- HBs positive conversion rate was 77.5%, and there was no significant difference between males and females （P〉0.05）. After the second full - access immunization the total rate of anti - HBs positive convertion was 80.16%, among them, the females＇ was higher than the males＇ （P〈0.05）. After the third full - access immunization in large doses, the anti - HBs positive conversion rate was 100%. Conclusion The anti - HBs positive conv- ersion rate among those irresponsive cases after the primary full- access immunization could reach to 100% after the second and third full- access immunization.
出处
《实用预防医学》
CAS
2007年第3期717-718,共2页
Practical Preventive Medicine
关键词
乙肝疫苗
阳转率
全程免疫
无应答
Hepatitis B vaccine
Positive conversion rate
Full-access immunization
Irresponsiveness
