摘要
目的探讨胎儿生长受限(FGR)与胰岛素样生长因子(IGF)和胰岛素样生长因子结合蛋白(IGFBP)的关系,为FGR的临床诊断和治疗提供理论依据和新思路。方法分别采集确诊FGR组和正常对照组孕妇羊水、静脉血和胎儿脐血标本,采用放射免疫方法测定标本中IGF-Ⅰ、IGF-Ⅱ、IGFBP-3含量。结果与对照组比较,FGR组IGF-Ⅰ、IGF-Ⅱ含量在脐血、母血以及羊水标本中均明显下降,差异具有统计学意义(P<0.001),IGFBP-3含量在脐血和羊水中明显上升,差异有统计学意义(P<0.001),但在母血中无明显差异(P>0.05)。结论IGF-Ⅰ、IGF-Ⅱ和IGFBP-3参与FGR的发生和发展,测定其含量可以作为诊断FGR的指标之一。
Objective To explore the relationship between fetal growth restriction （FGR） and insulin- like growth factor（IGF） and insulin - like growth factor binding protein（IGFBP）, and to provide theoretical evidences and new ways of clinical diagnosis and therapy for FGR. Methods Specimens of amniotic fliud, the maternal venous blood and cord blood in the diagnosed FGR group and the control group were collected, and the contents of IGF- I, IGF - 11 and IGFBP - 3 were determined by radioirnmunoassay. Results The levels of IGF - I and IGF - 11 in the FGR group were significantly lower as compared with the control group （ P〈 0.00 1）, the IGFBP - 3 levels were significantly higher in the cord blood and amniotic fli- ud （P〈0.001）, but not in the maternal venous blcod（P〉0.05）. Conclusions IGF- I, IGF- 11 and IGFBP- 3 are all involved in the pathogenesis and development of FGR, determining their contents may be one way of diagnosing FGR.
出处
《实用预防医学》
CAS
2007年第3期883-884,共2页
Practical Preventive Medicine
关键词
胎儿生长受限
胰岛素样生长因子
胰岛素样生长因子结合蛋白
Fetal growth restriction （FGR）
Insulin - like growth factor （IGF）
Insulin - like growth factor binding protein（GFBP）
