摘要
目的:观察吸入伊洛前列素治疗重症肺动脉高压的效果。方法:采用病例分析和文献复习方法。3例重症肺动脉高压女性患者,其中2例为特发性肺动脉高压,1例为系统性红斑狼疮合并肺动脉高压。3例患者均在常规治疗基础上吸入伊洛前列素10μg,每次吸入约10～15 min,每隔3 h一次,共6次。观察吸入前后体动脉压、心率、6 min步行距离和超声心动图各项指标的变化以及患者的不适反应。结果:3例患者6 min步行距离和肺动脉压力均有明显改善。结论:吸入伊洛前列素可以显著提高重症肺动脉高压患者活动耐力和降低肺动脉压力。
Objective：To observe the efficacy of inhaled iloprost in treating severe pulmonary hypertension Methods： Case analysis and literature review. Results： There were three women （mean age 32.7 years） diagnosed with severe pulmonary hypertension. Case one was diagnosed with systemic lupus erythematosus complicated pulmonary hypertension, the other two cases idiopathic pulmonary arterial hypertension. Inhalation of iloprost（ 10 μg/time,6 times per day）was administered to three patients on the basis of conventional therapy. Systemic pressure, heart rate, six-minute walking distance, echocardiographic parameters were measured before and after treatment. Improved six-minute walking test distance and significantly reduction of pulmonary arterial pressure were observed after inhalation of iloprost. Conclusion： Inhaled iloprost can markedly increase exercise capacity and alleviate pulmonary arterial hypertension in patient with severe pulmonary hypertension.
出处
《中国新药杂志》
CAS
CSCD
北大核心
2007年第12期973-976,共4页
Chinese Journal of New Drugs
关键词
肺动脉高压
伊洛前列素
吸入
pulmonary arterial hypertension
iloprost
inhalation
