彩色多普勒超声检测肝癌血流及其与MVD、VEGF表达的关系被引量：13

Relationship between blood flow assessed by color Doppler ultrasound and MVD,expression of VEGF in hepatocellular carcinoma

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摘要目的利用彩色多普勒超声检测肝癌血流并探讨其与微血管密度(MVD)、血管内皮生长因子(VEGF)的关系。方法采用彩色多普勒超声检测45例肝癌肿瘤血流信号,计测阻力指数(RI)、相对灌注率,血流分级。采用免疫组织化学技术检测肿瘤MVD及VEGF表达。结果肿瘤内阻力指数(RI)、相对灌注率、血流等级和MVD相关,相对灌注率、血流等级和VEGF表达相关,阻力指数与VEGF表达不相关。结论彩色多普勒超声联合上述免疫组织化学指标可从不同角度反映肝癌的血管生成特征,有助于对肝癌血管生成进行评价。 Objective To evaluate the relationship between blood flow and microvessel density （MVD）, expression of vascular endothelial growth factor （VEGF） in hepatocellular carcinoma. Methods Blood flow signals of hepatocellular carcinoma were preoperatively detected by color Doppler flow imaging in 45 patients and the resistance index （RI）, relative perfusion rate, blood flow grade were obtained for analysis. MVD, expression of VEGF in tumor was assessed immunohistochemically. Results There were correlations between RI, relative perfusion rate, blood flow grade and MVD. The expression of VEGF showed positive correlation to the relative perfusion rate, blood flow grade, but showed no significant correlation to RI. Conclusion Combination of color Doppler flow imaging and immunohistochemical parameters is useful for evaluating the angiogensis of hepatocellular carcinoma from different point of view.

作者肖际东沈守荣朱文晖周平

机构地区中南大学湘雅三医院超声科中南大学湘雅三医院消化内科

出处《中国医学影像技术》 CSCD 北大核心 2007年第6期884-887,共4页 Chinese Journal of Medical Imaging Technology

基金湖南省卫生科技计划课题基金(基B2005073) 湘雅三医院博士后基金(2005)资助

关键词肝细胞癌超声检查微血管密度血管内皮生长因子 Hepatocellular carcinoma Ultrasonography Microvessel density Vascular endothelial growth factor

分类号 R445.1 [医药卫生—影像医学与核医学] R735.7 [医药卫生—肿瘤]

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