摘要
目的探讨益气活血化痰法中药复方防治慢性阻塞性肺疾病(COPD)的临床疗效和作用机理。方法将76例COPD患者随机分为治疗组和对照组,对照组30例按照慢性阻塞性肺疾病防治全球倡仪(GOLD)方案根据病情轻重程度给予个体化治疗,治疗组46例在与对照组等同使用西药的基础上服用益气活血化痰法中药复方。评价两组病例治疗前后COPD患者的生活质量,检测血清中白介素-1(IL-1)、白介素-8(IL-8)、层粘连蛋白(LN)、透明质酸(HA)、Ⅲ型前胶原(PⅢP)转化生长因子-β(TGF-β)、碱性成纤维生长因子(b-FGF)含量。结果治疗组患者治疗后生活质量明显改善,血清中TGF-β、b-FGF含量降低,对照组血清中LN、HA、PⅢP含量升高。结论益气活血化痰法中药复方可以干预COPD气道重塑,减缓气流受限进展,改善患者生活质量。
Objective To investigate the clinical effect and mechanism of qi-replenishing, bloodactivating and phlegm-removing therapy to prevent and treat chronic obstructive pulmonary disease （COPD）. Method All 76 patients were randomly divided into the treatment group and control group. The control group （n = 30） was treated individually according to GOLD plan and patients＇ conditions. The treatment group （n = 46） was treated with qi-replenishing, blood-activating and phlegm-removing therapy besides the Western medicines as same as the control group. The living quality of COPD patents in two groups was evaluated before and after the treatment, and the serum contents of interleukin-1 （ IL- interleukin-8 （ IL-8 ）, laminin （LN）, hyaluronic acid （HA）, procollagen HI （ PIIIP）, transforming growth factor-β （TGF-β） and basic fibroblast grow factor （b-FGF） were detected. Result After the treatment the living quality of the patients in the treatment group was improved obviously, and the serum contents of TFG-I3 and b-FGF were decreased. In the control group the serum contents of LN, HA and P HIP were increased. Conclusion The therapy of qi-replenishing, blood-activating and phlegm-removing can intervene the reconstruction of the air tract in COPD patients, slow the development of air limitation and improve patient＇s living quality.
出处
《北京中医药大学学报》
CAS
CSCD
北大核心
2007年第6期419-422,共4页
Journal of Beijing University of Traditional Chinese Medicine
基金
国家自然科学基金资助项目(No.30200366)
关键词
慢性阻塞性肺疾病
益气活血化痰法
临床疗效
作用机理
chronic obstructive pulmonary disease
qi-replenishing, blood-activating and phlegmremoving therapy
clinical curative effect
mechanism
