摘要
目的:探讨抗生素泰能和中药血必净对降低腹腔重症感染血浆内毒素、炎症因子的作用。方法:盲肠结扎穿孔法建立腹腔重症感染大鼠模型,分别给予泰能、血必净、泰能加血必净或不予治疗,测定血浆内毒素(LPS)、肿瘤坏死因子(TNF-α)、白细胞介素-6(IL-6)及白细胞介素-10(IL-10),比较各组间差异。结果:泰能血必净联合用药组血浆内毒素、TNF-α、IL-6水平低于对照组(P<0.01),IL-6/IL-10低于其他各组(P<0.05)。结论:腹腔重症感染时使用血必净能降低血浆内膏素、TNF-α、IL-6水平,联合应用泰能和血必净两者协同作用,能有效地降低IL-6/IL-10比值。
Objective To investigate the effect of reducing plasma endotoxin and inflammatory mediators in severe intra-abdominal infection by combining the antibiotic Imipenem with Chinese herbs Xuebijing（血必净） Methods Abdominal infection animal models were established by ligation of thc recum and punctur. One hundred rats were randomly divided into 5 groups, 20 rats each. One group was the sham operation group. To the other 4 groups Imipenem, Xuebi- jing, Imipenem with Xucbijing was given respectively or none for thc control group. Then thc plasma endotoxin, tumor necrosis factor-a（TNF-α）, interleukin-6（IL-6） and intcrlcukin-10（IL-10） levels were measured and compared. Resulls The plasma indotoxin, TNF-α and IL-6 levels in the combined medication group were lower than those in the control group（ P 〈 0.01 ）. The IL-6/IL10 ratio was also lower than in any other group （ P 〈 0.05 ）. Conclusion The combination of Chinese herbs Xuebijing and antibiotc Imipenem in the treatment of abdominal infection can decrease the plasma levels of endotoxin, TNF-α, IL-6, and the IL-6/IL-10, thus improving the therapeutic result.
出处
《中国中西医结合外科杂志》
CAS
2007年第3期265-267,共3页
Chinese Journal of Surgery of Integrated Traditional and Western Medicine
