摘要
以DL-丝氨酸为原料经过酯化、拆分和水解制备D-丝氨酸。使L-2,3-二苯甲酰酒石酸(L-DBTA)与DL-丝氨酸甲酯在无水乙醇中于60℃反应形成非对映体盐,冷却到0℃,D-丝氨酸甲酯.L-DBTA二盐析出,过滤后再经水解,得到D-丝氨酸,总收率为74.8%,旋光纯度达到98%以上。
A new method for the preparation of D - serine from DL - serine was tested. Reaction of DL - serine and methanol in the presence of SOCl2 obtained DL - serine methyl ester. The ester reacted with L - 2,3 - dibenzoyl tartaric acid in ethanol at 60℃ formed L- serine and D- serine methyl ester L-2,3 -dibenzoyl tartrate, which precipitated from the mixture when the solution was cooled to 0 - 5 ℃. Hydrolysis of D - serine methyl ester L-2,3 -dibenzoyl tartrate gave D -serine with yield of 74.8% and optical purity 98%.
出处
《氨基酸和生物资源》
CAS
2007年第2期40-41,共2页
Amino Acids & Biotic Resources
