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光生物调节及糖皮质激素治疗类固醇肌病的前景 被引量:4

Photobiomodulation for glucocorticoid-induced steroid myopathy
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摘要 目的:综述糖皮质激素引起类固醇肌病的机制及其传统治疗方法和具有前景的光生物调节疗法。资料来源:应用计算机检索Medline、Ovoid和Springer1970/2007与糖皮质激素类固醇肌病及其疗法相关的文章,检索词“glucocorticoid,myopathy,therapy,low intensity laser therapy”,并限定文章语言为English。同时在中国全文数据库中检索,检索词“糖皮质激素,类固醇肌病”,并限定文章语言为中文。资料选择:对资料进行初审,纳入标准:糖皮质激素引起类固醇肌病的机制及其主要疗法的文献。排除标准:重复性研究。资料提炼:共收集到133篇相关文献。在选择和分析的基础上,排除重复或类似研究,最终提炼出48篇文献进行分类整理。资料综合:长期使用或大量使用糖皮质激素可以导致类固醇肌病的发生。通过糖皮质激素受体介导的信号转导,糖皮质激素可以正向或者负向调节相关基因的表达,从而产生如加快蛋白降解和减慢蛋白合成等相关效应。细胞模型或动物模型的实验表明,糖皮质激素可以从对骨骼肌能量代谢、氨基酸平衡、蛋白质代谢和成肌等方面的干扰而破坏骨骼肌细胞的内稳态,这可能是糖皮质激素引起类固醇肌病的机制。激活MAPKs信号途径或G蛋白耦联受体信号途径可能抑制糖皮质激素的信号转导。结论:激素疗法和运动疗法可以治疗类固醇肌病。光生物调节作用可以激活细胞MAPKs信号途径和G蛋白耦联受体信号途径,提示光生物调节作用是治疗类固醇肌病的一种潜在的疗法。 OBJECTIVE: To review the possible mechanism of glucocorticoid inducing steroid myopathy, and compare its routine therapy with the promising photobiomodulation. DATA SOURCES: An online search of Medline, Ovoid and Springer databases was undertaken to identify the articles of glucocorticoid inducing steroid myopathy and the corresponding therapies published in English from 1970 to 2007 by using the keywords of "glucocorticoid, myopathy, therapy, low intensity laser therapy". Similarly, the relevant articles published in Chinese were also searched from the Chinese National Knowledge Infrastructure with the keywords of "glucocorticoid, steroid myopathy". STUDY SELECTION: After the primary check, the articles related to the mechanism of glucocorticoid inducing steroid myopathy and its therapies were selected. The repetitive studies were excluded. DATA EXTRACTION: Totally 133 articles were collected and 48 articles of them were used in this review after the repeated or similar researches were deleted. DATA SYNTHESIS: Long-term or high-dose glucocorticoid treatment can result in steroid myopathy. After being activated by glucocorticoid, glucocorticoid receptors can mediate several gene expressions positively or negatively, which is followed by many biological responses such as accelerating protein breakdown and slowing down protein synthesis. The results of cell or animal model studies show that glucocorticoid interferes with energy metabolism, amino acid balance, protein metabolism of skeletal muscle cells and myogenesis so as to spoil the cellular homeostasis, which may be the mechanism of glucocorticoid inducing steroid myopathy. The MAPKs signals or G protein coupled receptor signals may depress the signal transduction of glucocorticoid and its receptors. CONCLUSION: Hormone therapy and appropriate training can reduce the intensity of steroid myopathy. Photobiomodulation can activate the signal transduction involved in MAPKs or G protein coupled receptors, indicating the potential application of photobiomodulation to treat steroid myopathy,
出处 《中国组织工程研究与临床康复》 CAS CSCD 北大核心 2007年第22期4399-4404,共6页 Journal of Clinical Rehabilitative Tissue Engineering Research
基金 国家自然科学基金(NSFC60478048)~~
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参考文献48

  • 1LaPier TK.Glucocorticoid-induced muscle atrophy.The role of exercise in treatment and prevention.J Cardiopulm Rehabil 1997;17(2):76-84
  • 2王彤,殷凯生,包丽华,张静謦.长期吸入糖皮质激素的哮喘患者对骨密度和骨代谢的影响[J].中国临床康复,2003,7(12):1781-1783. 被引量:17
  • 3Cheung K,Hume P,Maxwell L.Delayed onset muscle soreness:treatment strategies and performance factors.Sports Med 2003;33(2):145-164
  • 4李建萍,潘瑞福.肾上腺皮质类固醇肌病[J].国外医学(神经病学.神经外科学分册),2000,27(1):43-46. 被引量:7
  • 5Konno S.Hydroxyl radical formation in skeletal muscle of rats with glucocorticoid-induced myopathy.Neurochem Res 2005;30(5):669-675
  • 6Kanda F,Okuda S,Matsushita T,et al.Steroid myopathy:pathogenesis and effects of growth hormone and insulin-like growth factor-Ⅰ administration.Horm Res 2001;56 Suppl 1:24-28
  • 7Chrousos GP,Kino T.Intracellular glucocorticoid signaling:a formerly simple system turns stochastic.Sci STKE 2005;2005(304):pe48
  • 8Kino T,Tiulpakov A,Ichijo T,et al.G protein beta interacts with the glucocorticoid receptor and suppresses its transcriptional activity in the nucleus.J Cell Biol 2005;169(6):885-896
  • 9Groves TC,Wagner GF,DiMattia GE.cAMP signaling can antagonize potent glucocorticoid post-transcriptional inhibition of stanniocalcin gene expression.J Endocrinol 2001;171(3):499-516
  • 10Dimitriadis G,Leighton B,Parry-Billings M,et al.Effects of glucocorticoid excess on the sensitivity of glucose transport and metabolism to insulin in rat skeletal muscle.Biochem J 1997;321 (Pt 3):707-712

二级参考文献34

  • 1[1]Case Record of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 11-1997. A 51-year-old man with COPD and generalized muscle weakness. [clinical conference]. New Eng J Med, 1997, 336(15): 1079
  • 2[2]Hirano M, Ott BR, Raps EC, et al. Acute quadriplegic myopathy: a complication of treatment with steroids, nondepolarizing blocking agents, or both. Neurology, 1992, 42(11): 2082
  • 3[3]Nates JL, Cooper DJ, Day B, et al. Acute weakness syndromes in critical ill patients-areappraisal. Anaesth Intensive Care, 1997, 25(5): 502
  • 4[4]Bielefeld P. Present status of cortisone myopathy. Rev Med Interne, 1996, 17(3):255
  • 5[5]Mastaglia FL. Adverse effects of drugs on muscle. Drug, 1982, 24(4): 304
  • 6Gagnon L.Boulet LP,Brown J.Dearosiers T.Influence of inbaled corticosteroids and dietary intake on bone density aud metablism in patients with moderate to severe asthma.J Am Dies Assoc 1997;97(120:1401-6.
  • 7Zhu JP,Li Xu HY,et al.The effect of inhaled glucocorticoid of cortex steroids for adult bone metastasis.Zhongguo Linchuong Yixue(Chin Clin Med):2000;7(1):71.
  • 8Xiong H,Jiang JJ,Zhang QF,et al Drugs therapy of osteoporosis.Xiandai Kangfu (Mod Rehabil)2001;5(4B);13-51.
  • 9Blake GM,Fogelman I.Bone densitometry.steroids and osteoporosis.Curr Opin Nephrol Hypertens 2002;11(6):641-7.
  • 10Kanis JA,Melton LJ,3rd.Christiansen C.Johnston CC,Khaltaev N.The diagnosis of calciumbinding proteins and vitamin K.J Bone Miner Res 1994;9(8):1137-41.

共引文献27

同被引文献49

  • 1胡珏,周文斌,李静,肖波,杨晓苏,吴志国,梁静慧.成人型近端脊髓性肌萎缩症的临床和肌肉病理学研究[J].中国神经免疫学和神经病学杂志,2005,12(3):157-159. 被引量:1
  • 2刘吉良,张凤芝.药源性类固醇肌病(2例肌活检病理及文献复习)[J].脑与神经疾病杂志,1995,3(3):180-180. 被引量:2
  • 3朱汉民.活性维生素D和骨质疏松症防治[J].中华医学信息导报,2005,20(17):22-22. 被引量:10
  • 4DiMauro S, Lamperti C. Muscle glycogenoses[J]. Muscle & Nerve, 2001,24:984-999.
  • 5Bowyer SL, LaMothe MP, Hollister JR. Steroid myopathy: incidence and detection in a population with asthma[J]. J Allergy Clin Immunol, 1985,76:234-242.
  • 6Mitsui T, Umaki Y, Nagasawa M, et al. Mitochondrial damage in patients with long-term corticosteroid therapy: development of oculoskeletal symptoms similar to mitochondrial disease[J]. Acta Neuropathologica, 2002,104:260-266.
  • 7Mastaglia FL. Adverse effects of drugs on muscle[J]. Drugs, 1982, 24:304-321.
  • 8Li BG, Hasselgren PO, Fang CH, et al. Insulin-like growth factor-1 blocks dexamethasone-induced protein degradation in cultured myotubes by inhibiting multiple proteolytic pathways[J]. The Journal of burn care & rehabilitation, 2004, 25:112-118.
  • 9Te Pas MF, De Jong PR, Verburg FJ, et al. Glucocorticoid inhibition of C2C12 proliferation rate and differentiation capacity in relation to mRNA levels of the MRF gene family[J]. Mol Biol Rep, 2000, 27:87-98.
  • 10Kaneko K, Yamazaki O, Miyatake T. Correlation between steroid myopathy and the elevated serum lactic dehydrogenase (LDH) 1, 2, and 3 isoenzymes[J]. Muscle Nerve, 1993,16:1135-1136.

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